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A myeloid cell-binding adenovirus efficiently targets gene transfer to the lung and escapes liver tropism.
Published in:
Gene Therapy, 2013, v. 20, n. 7, p. 733, doi. 10.1038/gt.2012.91
By:
- Alberti, M O;
- Deshane, J S;
- Chaplin, D D;
- Pereboeva, L;
- Curiel, D T;
- Roth, J C
Publication type:
Article
Cell vehicle targeting strategies.
Published in:
Gene Therapy, 2008, v. 15, n. 10, p. 716, doi. 10.1038/gt.2008.38
By:
- Roth, J. C.;
- Curiel, D. T.;
- Pereboeva, L.
Publication type:
Article
Significant alterations of biodistribution and immune responses in Balb/c mice administered with adenovirus targeted to CD40(+) cells.
Published in:
Gene Therapy, 2008, v. 15, n. 4, p. 298, doi. 10.1038/sj.gt.3303085
By:
- Huang, D.;
- Pereboev, A. V.;
- Korokhov, N.;
- He, R.;
- Larocque, L.;
- Gravel, C.;
- Jaentschke, B.;
- Tocchi, M.;
- Casley, W. L.;
- Lemieux, M.;
- Curiel, D. T.;
- Chen, W.;
- Li, X.
Publication type:
Article
Direct selection of targeted adenovirus vectors by random peptide display on the fiber knob.
Published in:
Gene Therapy, 2007, v. 14, n. 20, p. 1448, doi. 10.1038/sj.gt.3303007
By:
- Miura, Y.;
- Yoshida, K.;
- Nishimoto, T.;
- Hatanaka, K.;
- Ohnami, S.;
- Asaka, M.;
- Douglas, J. T.;
- Curiel, D. T.;
- Yoshida, T;
- Aoki, K.
Publication type:
Article
Targeting EGFR with metabolically biotinylated fiber-mosaic adenovirus.
Published in:
Gene Therapy, 2007, v. 14, n. 8, p. 627, doi. 10.1038/sj.gt.3302916
By:
- Pereboeva, L.;
- Komarova, S.;
- Roth, J.;
- Ponnazhagan, S.;
- Curiel, D. T.
Publication type:
Article
Directing adenovirus across the blood–brain barrier via melanotransferrin (P97) transcytosis pathway in an in vitro model.
Published in:
Gene Therapy, 2007, v. 14, n. 6, p. 523, doi. 10.1038/sj.gt.3302888
By:
- Tang, Y.;
- Han, T.;
- Everts, M.;
- Zhu, Z. B.;
- Gillespie, G. Y.;
- Curiel, D. T.;
- Wu, H.
Publication type:
Article
Infectivity enhancement for adenoviral transduction of canine osteosarcoma cells.
Published in:
Gene Therapy, 2006, v. 13, n. 5, p. 389, doi. 10.1038/sj.gt.3302674
By:
- L. P. Le;
- Rivera, A. A.;
- Glasgow, J. N.;
- Ternovoi, V. V.;
- H. Wu;
- M. Wang;
- Smith, B. F.;
- Siegal, G. P.;
- Curiel, D. T.
Publication type:
Article
Transcriptional targeting of adenoviral vector through the CXCR4 tumor-specific promoter.
Published in:
2006
By:
- Zhu, Z. B.;
- Makhija, S. K.;
- Lu, B.;
- Wang, M.;
- Kaliberova, L.;
- Liu, B.;
- Rivera, A. A.;
- Nettelbeck, D. M.;
- Mahasreshti, P. J.;
- Leath, C. A.;
- Yamaoto, M.;
- Alvarez, R. D.;
- Curiel, D. T.
Publication type:
Correction Notice
An adenovirus vector with a chimeric fiber incorporating stabilized single chain antibody achieves targeted gene delivery.
Published in:
Gene Therapy, 2006, v. 13, n. 1, p. 88, doi. 10.1038/sj.gt.3302603
By:
- Hedley, S. J.;
- Auf der Maur, A.;
- Hohn, S.;
- Escher, D.;
- Barberis, A.;
- Glasgow, J. N.;
- Douglas, J. T.;
- Korokhov, N.;
- Curiel, D. T.
Publication type:
Article
A human adenoviral vector with a chimeric fiber from canine adenovirus type 1 results in novel expanded tropism for cancer gene therapy.
Published in:
Gene Therapy, 2005, v. 12, n. 23, p. 1696, doi. 10.1038/sj.gt.3302588
By:
- Stoff-Khalili, M. A.;
- Rivera, A. A.;
- Glasgow, J. N.;
- Le, L. P.;
- Stoff, A.;
- Everts, M.;
- Tsuruta, Y.;
- Kawakami, Y.;
- Bauerschmitz, G. J.;
- Mathis, J. M.;
- Pereboeva, L.;
- Seigal, G. P.;
- Dall, P.;
- Curiel, D. T.
Publication type:
Article
Selective induction of tumor-associated antigens in murine pulmonary vasculature using double-targeted adenoviral vectors.
Published in:
Gene Therapy, 2005, v. 12, n. 13, p. 1042, doi. 10.1038/sj.gt.3302491
By:
- Everts, M.;
- Kim-Park, S.-A.;
- Preuss, M. A.;
- Passineau, M. J.;
- Glasgow, J. N.;
- Pereboev, A. V.;
- Mahasreshti, P. J.;
- Grizzle, W. E.;
- Reynolds, P. N.;
- Curiel, D. T.
Publication type:
Article
Primary adenovirus-specific cytotoxic T lymphocyte response occurs after viral clearance and liver enzyme elevation.
Published in:
Gene Therapy, 2005, v. 12, n. 13, p. 1079, doi. 10.1038/sj.gt.3302494
By:
- Chen, J.;
- Zajac, A. J.;
- McPherson, S. A.;
- Hsu, H.-C.;
- Yang, P.;
- Wu, Q.;
- Xu, X.;
- Wang, X.;
- Fujihashi, K.;
- Curiel, D. T.;
- Mountz, J. D.
Publication type:
Article
Evaluation of tumor-specific promoter activities in melanoma.
Published in:
2005
By:
- Lu, B.;
- Makhija, S. K.;
- Nettelbeck, D. M.;
- Rivera, A. A.;
- Wang, M.;
- Komarova, S.;
- Zhou, F.;
- Yamamoto, M.;
- Haisma, H. J.;
- Alvarez, R. D.;
- Curiel, D. T.;
- Zhu, Z. B.
Publication type:
Abstract
Noninvasive dual modality in vivo monitoring of the persistence and potency of a tumor targeted conditionally replicating adenovirus.
Published in:
Gene Therapy, 2005, v. 12, n. 1, p. 87, doi. 10.1038/sj.gt.3302387
By:
- Kanerva, A;
- Zinn, K R;
- Peng, K-W;
- Ranki, T;
- Kangasniemi, L;
- Chaudhuri, T R;
- Desmond, R A;
- Wang, M;
- Takayama, K;
- Hakkarainen, T;
- Alfthan, H;
- Stenman, U-H;
- Curiel, D T;
- Hemminki, A
Publication type:
Article
Mesothelin-mediated targeting of adenoviral vectors for ovarian cancer gene therapy.
Published in:
Gene Therapy, 2005, v. 12, n. 2, p. 187, doi. 10.1038/sj.gt.3302404
By:
- Breidenbach, M;
- Rein, D T;
- Everts, M;
- Glasgow, J N;
- Wang, M;
- Passineau, M J;
- Alvarez, R D;
- Korokhov, N;
- Curiel, D T
Publication type:
Article
Combining high selectivity of replication with fiber chimerism for effective adenoviral oncolysis of CAR-negative melanoma cells.
Published in:
Gene Therapy, 2004, v. 11, n. 23, p. 1694, doi. 10.1038/sj.gt.3302346
By:
- Rivera, A A;
- Davydova, J;
- Schierer, S;
- Wang, M;
- Krasnykh, V;
- Yamamoto, M;
- Curiel, D T;
- Nettelbeck, D M
Publication type:
Article
Preclinical evaluation of a class of infectivity-enhanced adenoviral vectors in ovarian cancer gene therapy.
Published in:
Gene Therapy, 2004, v. 11, n. 10, p. 874, doi. 10.1038/sj.gt.3302249
By:
- Wu, H.;
- Han, T.;
- Lam, J. T.;
- Leath, C. A.;
- Dmitriev, I.;
- Kashentseva, E.;
- Barnes, M. N.;
- Alvarez, R. D.;
- Curiel, D. T.
Publication type:
Article
Combined transcriptional and transductional targeting improves the specificity and efficacy of adenoviral gene delivery to ovarian carcinoma.
Published in:
Gene Therapy, 2003, v. 10, n. 14, p. 1198, doi. 10.1038/sj.gt.3301974
By:
- Barker, S D;
- Dmitriev, I P;
- Nettelbeck, D M;
- Liu, B;
- Rivera, A A;
- Alvarez, R D;
- Curiel, D T;
- Hemminki, A
Publication type:
Article
CAR-binding ablation does not change biodistribution and toxicity of adenoviral vectors.
Published in:
Gene Therapy, 2001, v. 8, n. 17, p. 1347, doi. 10.1038/sj.gt.3301515
By:
- Alemany, R;
- Curiel, D T
Publication type:
Article
A novel system for mitigation of ectopic transgene expression induced by adenoviral vectors.
Published in:
Gene Therapy, 2001, v. 8, n. 16, p. 1271, doi. 10.1038/sj.gt.3301511
By:
- Reynolds, P N;
- Holmes, M D;
- Adachi, Y;
- Kaliberova, L;
- Curiel, D T
Publication type:
Article
Recombinant adenovirus expressing adeno-associated virus cap and rep proteins supports production of high-titer recombinant adeno-associated virus.
Published in:
Gene Therapy, 2001, v. 8, n. 9, p. 704, doi. 10.1038/sj.gt.3301454
By:
- Zhang, H-G;
- Wang, Y M;
- Xie, J F;
- Liang, X;
- Hsu, H-C;
- Zhang, X;
- Douglas, J;
- Curiel, D T;
- Mountz, J D
Publication type:
Article
THE IN VITRO APPLICATION OF CHEMOTHERAPY IN THE TREATMENT OF PANCREATIC CANCER.
Published in:
HPB Surgery, 1996, v. 9, n. S2, p. 49
By:
- Vickers, S. M.;
- Rosenfeld, M.;
- Rabem, D.;
- Sampson, L. K.;
- Curiel, D. T.
Publication type:
Article
Retargeting of adenoviral vectors to neurons using the HC fragment of tetanus toxin.
Published in:
Gene Therapy, 2000, v. 7, n. 18, p. 1584, doi. 10.1038/sj.gt.3301270
By:
- Schneider, H;
- Groves, M;
- Mühle, C;
- Reynolds, P N;
- Knight, A;
- Themis, M;
- Carvajal, J;
- Scaravilli, F;
- Curiel, D T;
- Fairweather, N F;
- Coutelle, C
Publication type:
Article
Fractionated radiation therapy in combination with adenoviral delivery of the cytosine deaminase gene and 5-fluorocytosine enhances cytotoxic and antitumor effects in human colorectal and cholangiocarcinoma models.
Published in:
Gene Therapy, 2000, v. 7, n. 12, p. 1019, doi. 10.1038/sj.gt.3301196
By:
- Stackhouse, M A;
- Pederson, L C;
- Grizzle, W E;
- Curiel, D T;
- Gebert, J;
- Haack, K;
- Vickers, S M;
- Mayo, M S;
- Buchsbaum, D J
Publication type:
Article
Adenovirus-mediated ribozyme targeting of HER-2/neu inhibits in vivo growth of breast cancer cells.
Published in:
Gene Therapy, 2000, v. 7, n. 3, p. 241, doi. 10.1038/sj.gt.3301065
By:
- Suzuki, T;
- Anderegg, B;
- Ohkawa, T;
- Irie, A;
- Engebraaten, O;
- Halks-Miller, M;
- Holm, P S;
- Curiel, D T;
- Kashani-Sabet, M;
- Scanlon, K J
Publication type:
Article
Genetically modified CD34+ cells as cellular vehicles for gene delivery into areas of angiogenesis in a rhesus model.
Published in:
Gene Therapy, 2000, v. 7, n. 1, p. 43, doi. 10.1038/sj.gt.3301054
By:
- Gómez-Navarro, J;
- Contreras, J L;
- Arafat, W;
- Jiang, X L;
- Krisky, D;
- Oligino, T;
- Marconi, P;
- Hubbard, B;
- Glorioso, J C;
- Curiel, D T;
- Thomas, J M
Publication type:
Article
Considerations and challenges for the achievement of targeted gene delivery.
Published in:
Gene Therapy, 1999, v. 6, n. 9, p. 1497, doi. 10.1038/sj.gt.3301038
By:
- Curiel, D T
Publication type:
Article
Tumor-specific gene transfer via an adenoviral vector targeted to the pan-carcinoma antigen EpCAM.
Published in:
Gene Therapy, 1999, v. 6, n. 8, p. 1469, doi. 10.1038/sj.gt.3300969
By:
- Haisma, H J;
- Pinedo, H M;
- van Rijswijk, A;
- van der Meulen-Muileman, I;
- Sosnowski, B A;
- Ying, W;
- van Beusechem, V W;
- Tillman, B W;
- Gerritsen, W R;
- Curiel, D T
Publication type:
Article
Insertion of an RGD motif into the HI loop of adenovirus fiber protein alters the distribution of transgene expression of the systemically administered vector.
Published in:
Gene Therapy, 1999, v. 6, n. 7, p. 1336, doi. 10.1038/sj.gt.3300941
By:
- Reynolds, P N;
- Dmitriev, I;
- Curiel, D T
Publication type:
Article
Phenotypic knock-out of the latent membrane protein 1 of Epstein–Barr virus by an intracellular single-chain antibody.
Published in:
Gene Therapy, 1998, v. 5, n. 9, p. 1171
By:
- Piché, A;
- Kasono, K;
- Johanning, F;
- Curiel, T J;
- Curiel, D T
Publication type:
Article
Humoral and cellular immune responses of dogs immunized with a nucleic acid vaccine encoding human carcinoembryonic antigen.
Published in:
Gene Therapy, 1998, v. 5, n. 7, p. 865, doi. 10.1038/sj.gt.3300675
By:
- Smith, B F;
- Baker, H J;
- Curiel, D T;
- Jiang, W;
- Conry, R M
Publication type:
Article
Imaging and tissue biodistribution of 99mTc-labeled adenovirus knob (serotype 5).
Published in:
Gene Therapy, 1998, v. 5, n. 6, p. 798, doi. 10.1038/sj.gt.3300659
By:
- Zinn, K R;
- Douglas, J T;
- Smyth, C A;
- Liu, H-G;
- Wu, Q;
- Krasnykh, V N;
- Mountz, J D;
- Curiel, D T;
- Mountz, J M
Publication type:
Article
Gene therapy strategies for AIDS-related malignancies.
Published in:
Gene Therapy, 1997, v. 4, n. 12, p. 1284, doi. 10.1038/sj.gt.3300538
By:
- Curiel, T J;
- Piché, A;
- Kasono, K;
- Curiel, D T
Publication type:
Article
Use of a novel cross-linking method to modify adenovirus tropism.
Published in:
Gene Therapy, 1997, v. 4, n. 12, p. 1387, doi. 10.1038/sj.gt.3300541
By:
- Rogers, B E;
- Douglas, J T;
- Ahlem, C;
- Buchsbaum, D J;
- Frincke, J;
- Curiel, D T
Publication type:
Article
An intracellular anti-erbB-2 single-chain antibody is specifically cytotoxic to human breast carcinoma cells overexpressing erbB-2.
Published in:
Gene Therapy, 1997, v. 4, n. 4, p. 317, doi. 10.1038/sj.gt.3300372
By:
- Wright, M;
- Grim, J;
- Deshane, J;
- Kim, M;
- Strong, T V;
- Siegal, G P;
- Curiel, D T
Publication type:
Article
Immunization with a plasmid expressing pneumococcal surface protein A (PspA) can elicit protection against fatal infection with Streptococcus pneumoniae.
Published in:
Gene Therapy, 1997, v. 4, n. 4, p. 375, doi. 10.1038/sj.gt.3300401
By:
- McDaniel, L S;
- Loechel, F;
- Benedict, C;
- Greenway, T;
- Briles, D E;
- Conry, R M;
- Curiel, D T
Publication type:
Article
A three-dimensional assay for measurement of viral-induced oncolysis.
Published in:
Cancer Gene Therapy, 2007, v. 14, n. 4, p. 421, doi. 10.1038/sj.cgt.7701028
By:
- Lam, J. T.;
- Hemminki, A.;
- Kanerva, A.;
- Lee, K. B.;
- Blackwell, J. L.;
- Desmond, R.;
- Siegal, G. P.;
- Curiel, D. T.
Publication type:
Article
Vascular endothelial growth factor promoter-based conditionally replicative adenoviruses for pan-carcinoma application.
Published in:
Cancer Gene Therapy, 2007, v. 14, n. 1, p. 105, doi. 10.1038/sj.cgt.7700991
By:
- Takayama, K.;
- Reynolds, P. N.;
- Adachi, Y.;
- Kaliberova, L.;
- Uchino, J.;
- Nakanishi, Y.;
- Curiel, D. T.
Publication type:
Article
Transductional targeting of adenovirus vectors for gene therapy.
Published in:
Cancer Gene Therapy, 2006, v. 13, n. 9, p. 830, doi. 10.1038/sj.cgt.7700928
By:
- Glasgow, J N;
- Everts, M;
- Curiel, D T
Publication type:
Article
Gene therapy for carcinoma of the breast.
Published in:
Cancer Gene Therapy, 2006, v. 13, n. 7, p. 633, doi. 10.1038/sj.cgt.7700929
By:
- Stoff-Khalili, M. A.;
- Dall, P.;
- Curiel, D. T.
Publication type:
Article
Employment of liver tissue slice analysis to assay hepatotoxicity linked to replicative and nonreplicative adenoviral agents.
Published in:
Cancer Gene Therapy, 2006, v. 13, n. 6, p. 606, doi. 10.1038/sj.cgt.7700934
By:
- Stoff-Khalili, M. A.;
- Rivera, A. A.;
- Le, L. P.;
- Stoff, A.;
- Everts, M.;
- Contreras, J. L.;
- Chen, D.;
- Teng, L.;
- Rots, M. G.;
- Haisma, H. J.;
- Rocconi, R. P.;
- Bauerschmitz, G. J.;
- Rein, D. T.;
- Yamamoto, M.;
- Siegal, G. P.;
- Dall, P.;
- Michael Mathis, J.;
- Curiel, D. T.
Publication type:
Article
Suppressor of cytokine signaling-1 expression by infectivity-enhanced adenoviral vector inhibits IL-6-dependent proliferation of multiple myeloma cells.
Published in:
Cancer Gene Therapy, 2006, v. 13, n. 2, p. 194, doi. 10.1038/sj.cgt.7700873
By:
- Yamamoto, M.;
- Nishimoto, N.;
- Davydova, J.;
- Kishimoto, T.;
- Curiel, D. T.
Publication type:
Article
The carcinoma-specific epithelial glycoprotein-2 promoter controls efficient and selective gene expression in an adenoviral context.
Published in:
Cancer Gene Therapy, 2006, v. 13, n. 2, p. 150, doi. 10.1038/sj.cgt.7700882
By:
- Gommans, W. M.;
- van Eert, S. J.;
- McLaughlin, P. M. J.;
- Harmsen, M. C.;
- Yamamoto, M.;
- Curiel, D. T.;
- Haisma, H. J.;
- Rots, M. G.
Publication type:
Article
Augmented adenovirus transduction of murine T lymphocytes utilizing a bi-specific protein targeting murine interleukin 2 receptor.
Published in:
Cancer Gene Therapy, 2015, v. 22, n. 4, p. 222, doi. 10.1038/cgt.2015.13
By:
- Beatty, M S;
- Timares, L;
- Curiel, D T
Publication type:
Article
Gene therapy for radioprotection.
Published in:
Cancer Gene Therapy, 2015, v. 22, n. 4, p. 172, doi. 10.1038/cgt.2015.8
By:
- Everett, W H;
- Curiel, D T
Publication type:
Article
Therapeutic adenoviral gene transfer of a glycosyltransferase for prevention of peritoneal dissemination and metastasis of gastric cancer.
Published in:
Cancer Gene Therapy, 2014, v. 21, n. 10, p. 427, doi. 10.1038/cgt.2014.46
By:
- Kawamura, Y. l.;
- Adachi, Y.;
- Curiel, D. T.;
- Kawashima, R.;
- Kannagi, R.;
- Nishimoto, N.;
- Dohi, T.
Publication type:
Article
Experimental virotherapy of chemoresistant pancreatic carcinoma using infectivity-enhanced fiber-mosaic oncolytic adenovirus.
Published in:
Cancer Gene Therapy, 2014, v. 21, n. 7, p. 264, doi. 10.1038/cgt.2014.26
By:
- Kaliberov, S A;
- Kaliberova, L N;
- Buchsbaum, D J;
- Curiel, D T
Publication type:
Article
Augmented adenovirus transduction of murine T lymphocytes utilizing a bi-specific protein targeting murine interleukin 2 receptor.
Published in:
Cancer Gene Therapy, 2013, v. 20, n. 8, p. 445, doi. 10.1038/cgt.2013.39
By:
- Beatty, M S;
- Curiel, D T
Publication type:
Article
Enhanced delivery of mda-7/IL-24 using a serotype chimeric adenovirus (Ad.5/3) improves therapeutic efficacy in low CAR prostate cancer cells.
Published in:
Cancer Gene Therapy, 2010, v. 17, n. 7, p. 447, doi. 10.1038/cgt.2009.91
By:
- Dash, R.;
- Dmitriev, I.;
- Su, Z.-z.,4;
- Bhutia, S. K.;
- Azab, B.;
- Vozhilla, N.;
- Yacoub, A.;
- Dent, P.;
- Curiel, D. T.;
- Sarkar, D.;
- Fisher, P. B.
Publication type:
Article
A cancer terminator virus eradicates both primary and distant human melanomas.
Published in:
Cancer Gene Therapy, 2008, v. 15, n. 5, p. 293, doi. 10.1038/cgt.2008.14
By:
- Sarkar, D.;
- Su, Z.-z.;
- Park, E.-S.;
- Vozhilla, N.;
- Dent, P.;
- Curiel, D. T.;
- Fisher, P. B.
Publication type:
Article

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