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A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication.
- Published in:
- Nature Medicine, 2015, v. 21, n. 4, p. 383, doi. 10.1038/nm.3820
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- Article
Transient in utero knockout (TIUKO) of C-MYC affects late lung and intestinal development in the mouse.
- Published in:
- BMC Developmental Biology, 2004, v. 4, p. 1
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- Publication type:
- Article
NRF2 is required for neonatal mouse beta cell growth by maintaining redox balance and promoting mitochondrial biogenesis and function.
- Published in:
- Diabetologia, 2024, v. 67, n. 3, p. 547, doi. 10.1007/s00125-023-06071-7
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- Article
Single-nucleus RNA sequencing of human pancreatic islets identifies novel gene sets and distinguishes β-cell subpopulations with dynamic transcriptome profiles.
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- Genome Medicine, 2023, v. 15, n. 1, p. 1, doi. 10.1186/s13073-023-01179-2
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- Article
Transcriptional Regulation of Human Dual Specificity Protein Phosphatase 1 (DUSP1) Gene by Glucocorticoids.
- Published in:
- PLoS ONE, 2010, v. 5, n. 10, p. 1, doi. 10.1371/journal.pone.0013754
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- Article
Structure-Function Analysis of p57<sup>KIP2</sup> in the Human Pancreatic Beta Cell Reveals a Bipartite Nuclear Localization Signal.
- Published in:
- Endocrinology, 2024, v. 165, n. 2, p. 1, doi. 10.1210/endocr/bqad197
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- Article
Impaired apoptosis and immune senescence– cause or effect?
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- Immunological Reviews, 2005, v. 205, n. 1, p. 130, doi. 10.1111/j.0105-2896.2005.00270.x
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- Article
cAMP opposes the glucose-mediated induction of the L-PK gene by preventing the recruitment of a complex containing ChREBP, HNF4α, and CBP.
- Published in:
- FASEB Journal, 2009, v. 23, n. 9, p. 2855, doi. 10.1096/fj.08-126631
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- Article
GLP-1 receptor agonists synergize with DYRK1A inhibitors to potentiate functional human β cell regeneration.
- Published in:
- Science Translational Medicine, 2020, v. 12, n. 530, p. 1, doi. 10.1126/scitranslmed.aaw9996
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- Article
Lessons From the First Comprehensive Molecular Characterization of Cell Cycle Control in Rodent Insulinoma Cell Lines.
- Published in:
- Diabetes, 2008, v. 57, n. 11, p. 3056, doi. 10.2337/db08-0393
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- Publication type:
- Article
Glucose infusion in mice: a new model to induce beta-cell replication.
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- 2007
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- Publication type:
- journal article
Glucose Infusion in Mice.
- Published in:
- Diabetes, 2007, v. 56, n. 7, p. 1792, doi. 10.2337/db06-1513
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- Publication type:
- Article
The Glucose-Mediated Induction of Pyruvate Kinase, but not Glucose-6-Phosphatase, Is Inhibited by Ly294002 and Ly303511 via a PI3Kinase-Independent Mechanism in HL1C Hepatomas.
- Published in:
- Diabetes, 2007, v. 56, p. A518
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- Publication type:
- Article
Biphasic Recruitment of ChREBP to the L-PK Gene Promoter by Glucose in INS-1 Derived 832/13 Cells.
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- Diabetes, 2007, v. 56, p. A518
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- Publication type:
- Article
Regulation of the L-PK And ACC Genes by Glucose and cAMP: Role of C/EBP Beta and ChREBP.
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- Diabetes, 2007, v. 56, p. A13
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- Publication type:
- Article
Mechanisms by which the thiazolidinedione troglitazone protects against sucrose-induced hepatic fat accumulation and hyperinsulinaemia.
- Published in:
- 2016
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- Publication type:
- journal article
Replication confers β cell immaturity.
- Published in:
- Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-02939-0
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- Article
Insights into beta cell regeneration for diabetes via integration of molecular landscapes in human insulinomas.
- Published in:
- Nature Communications, 2017, v. 8, n. 1, p. 1, doi. 10.1038/s41467-017-00992-9
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- Article
Regulation of Pdx1 by oxidative stress and Nrf2 in pancreatic beta-cells.
- Published in:
- Frontiers in Endocrinology, 2022, v. 13, p. 1, doi. 10.3389/fendo.2022.1011187
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- Article
Aberrant methylation underlies insulin gene expression in human insulinoma.
- Published in:
- Nature Communications, 2020, v. 11, n. 1, p. N.PAG, doi. 10.1038/s41467-020-18839-1
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- Article
Nrf2 Regulates β-Cell Mass by Suppressing β-Cell Death and Promoting β-Cell Proliferation.
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- 2022
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- Publication type:
- journal article
HB-EGF Signaling Is Required for Glucose-Induced Pancreatic β-Cell Proliferation in Rats.
- Published in:
- 2020
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- Publication type:
- journal article
Myc Is Required for Adaptive β-Cell Replication in Young Mice but Is Not Sufficient in One-Year-Old Mice Fed With a High-Fat Diet.
- Published in:
- 2019
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- Publication type:
- journal article
Activation of Nrf2 Is Required for Normal and ChREBPα-Augmented Glucose-Stimulated β-Cell Proliferation.
- Published in:
- 2018
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- Publication type:
- journal article
PKCζ Is Essential for Pancreatic β-Cell Replication During Insulin Resistance by Regulating mTOR and Cyclin-D2.
- Published in:
- 2016
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- Publication type:
- journal article
Induction of the ChREBPβ Isoform Is Essential for Glucose-Stimulated β-Cell Proliferation.
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- 2015
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- journal article
Human β-Cell Proliferation and Intracellular Signaling Part 2: Still Driving in the Dark Without a Road Map.
- Published in:
- Diabetes, 2014, v. 63, n. 3, p. 819, doi. 10.2337/db13-1146
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- Publication type:
- Article
Cytoplasmic-nuclear trafficking of G1/S cell cycle molecules and adult human β-cell replication: a revised model of human β-cell G1/S control.
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- 2013
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- Publication type:
- journal article
Cytoplasmic-Nuclear Trafficking of G1/S Cell Cycle Molecules and Adult Human β-Cell Replication.
- Published in:
- Diabetes, 2013, v. 62, n. 7, p. 2460, doi. 10.2337/db12-0778
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- Publication type:
- Article
Human Pancreatic β-Cell G1/S Molecule Cell Cycle Atlas.
- Published in:
- Diabetes, 2013, v. 62, n. 7, p. 2450, doi. 10.2337/db12-0777
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- Publication type:
- Article
Dendritic Cells Promote Macrophage Infiltration and Comprise a Substantial Proportion of Obesity-Associated Increases in CD11c<sup>+</sup> Cells in Adipose Tissue and Liver.
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- Diabetes, 2012, v. 61, n. 9, p. 2330, doi. 10.2337/db11-1523
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- Publication type:
- Article
ChREBP Mediates Glucose-Stimulated Pancreatic β-Cell Proliferation.
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- Diabetes, 2012, v. 61, n. 8, p. 2004, doi. 10.2337/db11-0802
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- Article
Activation of Protein Kinase C-ζ in Pancreatic β-Cells In Vivo Improves Glucose Tolerance and Induces β-Cell Expansion via mTOR Activation.
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- Diabetes, 2011, v. 60, n. 10, p. 2546, doi. 10.2337/db10-1783
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- Article
Parathyroid hormone-related protein enhances human ß-cell proliferation and function with associated induction of cyclin-dependent kinase 2 and cyclin E expression.
- Published in:
- 2010
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- Publication type:
- journal article
Parathyroid Hormone--Related Protein Enhances Human β-Cell Proliferation and Function With Associated Induction of Cyclin-Dependent Kinase 2 and Cyclin E Expression.
- Published in:
- Diabetes, 2010, v. 59, n. 12, p. 3131, doi. 10.2337/db09-1796
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- Publication type:
- Article
Induction of human beta-cell proliferation and engraftment using a single G1/S regulatory molecule, cdk6.
- Published in:
- 2010
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- Publication type:
- journal article
Induction of Human β-Cell Proliferation and Engraftment Using a Single G1/S Regulatory Molecule, cdk6.
- Published in:
- Diabetes, 2010, v. 59, n. 8, p. 1926, doi. 10.2337/db09-1776
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- Publication type:
- Article
Depletion of Liver Kupffer Cells Prevents the Development of Diet-Induced Hepatic Steatosis and Insulin Resistance.
- Published in:
- Diabetes, 2010, v. 59, n. 2, p. 347, doi. 10.2337/db09-0016
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- Publication type:
- Article