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Evaluation of a Novel Oncolytic Adenovirus Silencing SYVN1.
Published in:
International Journal of Molecular Sciences, 2022, v. 23, n. 23, p. 15430, doi. 10.3390/ijms232315430
By:
- Vermeulen, Christie;
- Brachtlova, Tereza;
- Tol, Nikki;
- van der Meulen-Muileman, Ida H.;
- Hodzic, Jasmina;
- van de Vrugt, Henri J.;
- van Beusechem, Victor W.
Publication type:
Article
Functional Screen for microRNAs Suppressing Anchorage-Independent Growth in Human Cervical Cancer Cells.
Published in:
International Journal of Molecular Sciences, 2022, v. 23, n. 9, p. 4791, doi. 10.3390/ijms23094791
By:
- Huseinovic, Angelina;
- Jaspers, Annelieke;
- van Splunter, Annina P.;
- Sørgård, Hanne;
- Wilting, Saskia M.;
- Swarts, Dorian R. A.;
- van der Meulen, Ida H.;
- van Beusechem, Victor W.;
- de Menezes, Renée X.;
- Steenbergen, Renske D. M.
Publication type:
Article
Biology of the mRNA Splicing Machinery and Its Dysregulation in Cancer Providing Therapeutic Opportunities.
Published in:
International Journal of Molecular Sciences, 2021, v. 22, n. 10, p. 5110, doi. 10.3390/ijms22105110
By:
- Blijlevens, Maxime;
- Li, Jing;
- van Beusechem, Victor W.;
- Chabot, Benoit
Publication type:
Article
Silencing Core Spliceosome Sm Gene Expression Induces a Cytotoxic Splicing Switch in the Proteasome Subunit Beta 3 mRNA in Non-Small Cell Lung Cancer Cells.
Published in:
International Journal of Molecular Sciences, 2020, v. 21, n. 12, p. 4192, doi. 10.3390/ijms21124192
By:
- Blijlevens, Maxime;
- Komor, Malgorzata A.;
- Sciarrillo, Rocco;
- Smit, Egbert F.;
- Fijneman, Remond J. A.;
- van Beusechem, Victor W.
Publication type:
Article
Intravenous administration of the conditionally replicative adenovirus Ad5-Δ24RGD induces regression of osteosarcoma lung metastases.
Published in:
Molecular Cancer, 2008, v. 7, p. 1, doi. 10.1186/1476-4598-7-9
By:
- Graat, Harm C. A.;
- van Beusechem, Victor W.;
- Schagen, Frederik H. E.;
- Witlox, M. Adhiambo;
- Kleinerman, Eugenie S.;
- Helder, Marco N.;
- Gerritsen, Winald R.;
- Kaspers, Gertjan J. L.;
- Wuisman, Paul I. J. M.
Publication type:
Article
Anatomical Differences Determine Distribution of Adenovirus after Convection-Enhanced Delivery to the Rat Brain.
Published in:
PLoS ONE, 2011, v. 6, n. 10, p. 1, doi. 10.1371/journal.pone.0024396
By:
- Idema, Sander;
- Caretti, Viola;
- Lamfers, Martine L. M.;
- van Beusechem, Victor W.;
- Noske, David P.;
- Peter Vandertop, W.;
- Dirven, Clemens M. F.
Publication type:
Article
A cell-based high-throughput screening assay for radiation susceptibility using automated cell counting.
Published in:
Radiation Oncology, 2015, v. 10, n. 1, p. 1, doi. 10.1186/s13014-015-0355-2
By:
- Hodzic, Jasmina;
- Dingjan, Ilse;
- Maas, Mariëlle J. P.;
- van der Meulen-Muileman, Ida H.;
- de Menezes, Renee X.;
- Heukelom, Stan;
- Verheij, Marcel;
- Gerritsen, Winald R.;
- Geldof, Albert A.;
- van Triest, Baukelien;
- van Beusechem, Victor W.
Publication type:
Article
Chemopreventive targeted treatment of head and neck precancer by Wee1 inhibition.
Published in:
Scientific Reports, 2020, v. 10, n. 1, p. 1, doi. 10.1038/s41598-020-58509-2
By:
- van Harten, Anne M.;
- de Boer, D. Vicky;
- Martens-de Kemp, Sanne R.;
- Buijze, Marijke;
- Ganzevles, Sonja H.;
- Hunter, Keith D.;
- Leemans, C. René;
- van Beusechem, Victor W.;
- Wolthuis, Rob M. F.;
- de Menezes, Renée X.;
- Brakenhoff, Ruud H.
Publication type:
Article
Analysis of small-sample clinical genomics studies using multi-parameter shrinkage: application to high-throughput RNA interference screening.
Published in:
BMC Medical Genomics, 2013, v. 6, n. Suppl 2, p. 1, doi. 10.1186/1755-8794-6-S2-S1
By:
- van de Wiel, Mark A.;
- de Menezes, Renée X.;
- Siebring-van Olst, Ellen;
- van Beusechem, Victor W.
Publication type:
Article
Host gene targets for novel influenza therapies elucidated by high-throughput RNA interference screens.
Published in:
FASEB Journal, 2012, v. 26, n. 4, p. 1372, doi. 10.1096/fj.11-193466
By:
- Meliopoulos, Victoria A.;
- Andersen, Lauren E.;
- Birrer, Katherine F.;
- Simpson, Kaylene J.;
- Lowenthal, John W.;
- Bean, Andrew G. D.;
- Stambas, John;
- Stewart, Cameron R.;
- Tompkins, S. Mark;
- van Beusechem, Victor W.;
- Fraser, Iain;
- Mhlanga, Musa;
- Barichievy, Samantha;
- Smith, Queta;
- Leake, Devin;
- Karpilow, Jon;
- Buck, Amy;
- Jona, Ghil;
- Tripp, Ralph A.
Publication type:
Article
Inhibition of angiogenesis and HGF-cMET-elicited malignant processes in human hepatocellular carcinoma cells using adenoviral vector-mediated NK4 gene therapy.
Published in:
Cancer Gene Therapy, 2005, v. 12, n. 12, p. 954, doi. 10.1038/sj.cgt.7700856
By:
- Heideman, Daniëlle A. M.;
- Overmeer, Renée M.;
- van Beusechem, Victor W.;
- Lamers, Wouter H.;
- Hakvoort, Theodorus B. M.;
- Snijders, Peter J. F.;
- Craanen, Mikael E.;
- Offerhaus, G. Johan A.;
- Meijer, Chris J. L. M.;
- Gerritsen, Winald R.
Publication type:
Article
Selective gene delivery toward gastric and esophageal adenocarcinoma cells via EpCAM-targeted adenoviral vectors.
Published in:
Cancer Gene Therapy, 2001, v. 8, n. 5, p. 342, doi. 10.1038/sj.cgt.7700313
By:
- Heideman, Daniëlle A M;
- Snijders, Peter J F;
- Craanen, Mikael E;
- Bloemena, Elisabeth;
- Meijer, Chris J L M;
- Meuwissen, Stefan G M;
- van Beusechem, Victor W;
- Pinedo, Herbert M;
- Curiel, David T;
- Haisma, Hidde J;
- Gerritsen, Winald R
Publication type:
Article
Targeting of adenoviral vectors through a bispecific single-chain antibody.
Published in:
Cancer Gene Therapy, 2000, v. 7, n. 6, p. 901, doi. 10.1038/sj.cgt.7700198
By:
- Haisma, Hidde J;
- Grill, Jacques;
- Curiel, David T;
- Hoogeland, Susan;
- van Beusechem, Victor W;
- Pinedo, Herbert M;
- Gerritsen, Winald R
Publication type:
Article
Adenovirus Armed With TNFa and IL2 Added to aPD-1 Regimen Mediates Antitumor Efficacy in Tumors Refractory to aPD-1.
Published in:
Frontiers in Immunology, 2021, v. 12, p. 1, doi. 10.3389/fimmu.2021.706517
By:
- Cervera-Carrascon, Victor;
- Quixabeira, Dafne C. A.;
- Santos, Joao M.;
- Havunen, Riikka;
- Milenova, Ioanna;
- Verhoeff, Jan;
- Heiniö, Camilla;
- Zafar, Sadia;
- Garcia-Vallejo, Juan J.;
- van Beusechem, Victor W.;
- de Gruijl, Tanja D.;
- Kalervo, Aino;
- Sorsa, Suvi;
- Kanerva, Anna;
- Hemminki, Akseli
Publication type:
Article
Defective sister chromatid cohesion is synthetically lethal with impaired APC/C function.
Published in:
Nature Communications, 2015, v. 6, n. 10, p. 8399, doi. 10.1038/ncomms9399
By:
- de Lange, Job;
- Faramarz, Atiq;
- Oostra, Anneke B.;
- de Menezes, Renee X.;
- van der Meulen, Ida H.;
- Rooimans, Martin A.;
- Rockx, Davy A.;
- Brakenhoff, Ruud H.;
- van Beusechem, Victor W.;
- King, Randall W.;
- de Winter, Johan P.;
- Wolthuis, Rob M. F.
Publication type:
Article
Sunitinib activates Axl signaling in renal cell cancer.
Published in:
International Journal of Cancer, 2016, v. 138, n. 12, p. 3002, doi. 10.1002/ijc.30022
By:
- van der Mijn, Johannes C.;
- Broxterman, Henk J.;
- Knol, Jaco C.;
- Piersma, Sander R.;
- De Haas, Richard R.;
- Dekker, Henk;
- Pham, Thang V.;
- Van Beusechem, Victor W.;
- Halmos, Balazs;
- Mier, James W.;
- Jiménez, Connie R.;
- Verheul, Henk M.W.
Publication type:
Article
Objective determination of the oncolytic potency of conditionally-replicating adenoviruses using mathematical modeling.
Published in:
Journal of Gene Medicine, 2010, v. 12, n. 7, p. 564, doi. 10.1002/jgm.1468
By:
- Idema, Sander;
- Dirven, Clemens M. F.;
- van Beusechem, Victor W.;
- Carette, Jan E.;
- Planqué, Robert;
- Noske, David P.;
- Lamfers, Martine L. M.;
- Vandertop, W. Peter
Publication type:
Article
Adenovirus retargeting to surface expressed antigens on oral mucosa.
Published in:
Journal of Gene Medicine, 2010, v. 12, n. 4, p. 365, doi. 10.1002/jgm.1447
By:
- van Zeeburg, Hester J. T.;
- van Beusechem, Victor W.;
- Huizenga, Aafke;
- Haisma, Hidde J.;
- Korokhov, Nick;
- Gibbs, Susan;
- René Leemans, C.;
- Brakenhoff, Ruud H.
Publication type:
Article
AdΔ24 and the p53-expressing variant AdΔ24-p53 achieve potent anti-tumor activity in glioma when combined with radiotherapy.
Published in:
Journal of Gene Medicine, 2007, v. 9, n. 12, p. 1046, doi. 10.1002/jgm.1113
By:
- Idema, Sander;
- Lamfers, Martine L.M.;
- van Beusechem, Victor W.;
- Noske, David P.;
- Heukelom, Stan;
- Moeniralm, Sharif;
- Gerritsen, Winald R.;
- Vandertop, W. Peter;
- Dirven, Clemens M.F.
Publication type:
Article
Replication-dependent transgene expression from a conditionally replicating adenovirus via alternative splicing to a heterologous splice-acceptor site.
Published in:
Journal of Gene Medicine, 2005, v. 7, n. 8, p. 1053, doi. 10.1002/jgm.754
By:
- Carette, Jan E.;
- Graat, Harm C. A.;
- Schagen, Frederik H. E.;
- Abou El Hassan, Mohamed A. I.;
- Gerritsen, Winald R.;
- van Beusechem, Victor W.
Publication type:
Article
Expression of p53, or targeting towards EGFR, enhances the oncolytic potency of conditionally replicative adenovirus against neuroblastoma.
Published in:
Journal of Gene Medicine, 2005, v. 7, n. 5, p. 584, doi. 10.1002/jgm.703
By:
- Geoerger, Birgit;
- van Beusechem, Victor W.;
- Opolon, Paule;
- Morizet, Jackie;
- Laudani, Lysiane;
- Lecluse, Yann;
- Barrois, Michel;
- Idema, Sander;
- Grill, Jacques;
- Gerritsen, Winald R.;
- Vassal, Gilles
Publication type:
Article
Suppression of tumor growth, invasion and angiogenesis of human gastric cancer by adenovirus-mediated expression of NK4.
Published in:
Journal of Gene Medicine, 2004, v. 6, n. 3, p. 317
By:
- Daniëlle A. M. Heideman;
- Victor W. van Beusechem;
- Elisabeth Bloemena;
- Peter J. F. Snijders;
- Mikael E. Craanen;
- G. Johan A. Offerhaus;
- Patrick W. B. Derksen;
- Michiel de Bruin;
- M. Adhiambo Witlox;
- Bonnie Molenaar;
- Chris J. L. M. Meijer;
- Winald R. Gerritsen
Publication type:
Article
Cyclophosphamide Increases Transgene Expression Mediated by an Oncolytic Adenovirus in Glioma-Bearing Mice Monitored by Bioluminescence Imaging.
Published in:
Molecular Therapy, 2006, v. 14, n. 6, p. 779, doi. 10.1016/j.ymthe.2006.08.008
By:
- Lamfers, Martine L. M.;
- Fulci, Giulia;
- Gianni, Davide;
- Tang, Yi;
- Kurozumi, Kazuhiko;
- Kaur, Balveen;
- Moeniralm, Sharif;
- Saeki, Yoshinaga;
- Carette, Jan E.;
- Weissleder, Ralph;
- Vandertop, W. Peter;
- van Beusechem, Victor W.;
- Dirven, Clemens M. F.;
- Chiocca, E. Antonio
Publication type:
Article
15. Genetically Targeted Adenovirus Vector Carrying Reovirus σ1-Based Attachment Protein for Improved Systemic Gene Delivery.
Published in:
Molecular Therapy, 2006, v. 13, p. S6, doi. 10.1016/j.ymthe.2006.08.026
By:
- Schagen, Frederik H.E.;
- Graat, Harm C.A.;
- Carette, Jan E.;
- Dermody, Terence S.;
- vanGeer, Michael A.;
- van Beusechem, Victor W.
Publication type:
Article
641. Retargeting Adenoviruses to Surface Expressed Antigens on Oral Mucosa.
Published in:
Molecular Therapy, 2006, v. 13, p. S247, doi. 10.1016/j.ymthe.2006.08.717
By:
- van Zeeburg, Hester J. T.;
- Huizenga, Aafke;
- Korokhov, N.;
- van Beusechem, Victor W.;
- Brakenhoff, Ruud H.
Publication type:
Article
Genetic Targeting of Adenovirus Vectors Using a Reovirus σ1-Based Attachment Protein.
Published in:
Molecular Therapy, 2006, v. 13, n. 5, p. 997, doi. 10.1016/j.ymthe.2005.11.019
By:
- Schagen, Frederik H.E.;
- Wensveen, Felix M.;
- Carette, Jan E.;
- Dermody, Terence S.;
- Gerritsen, Winald R.;
- van Beusechem, Victor W.
Publication type:
Article
Oncolytic Adenovirus Expressing a p53 Variant Resistant to Degradation by HPV E6 Protein Exhibits Potent and Selective Replication in Cervical Cancer
Published in:
Molecular Therapy, 2005, v. 12, n. 6, p. 1083, doi. 10.1016/j.ymthe.2005.06.443
By:
- Heideman, Daniëlle A.M.;
- Steenbergen, Renske D.M.;
- van der Torre, Jaco;
- Scheffner, Martin;
- Alemany, Ramon;
- Gerritsen, Winald R.;
- Meijer, Chris J.L.M.;
- Snijders, Peter J.F.;
- van Beusechem, Victor W.
Publication type:
Article
526. Conditionally Replicative Adenoviruses Designed to Restore Defects in the p53 Pathway for Effective Virotherapy of Cancer
Published in:
2005
By:
- van Beusechem, Victor W.;
- Heideman, Danielle A.M.;
- Carette, Jan E.;
- Scheffner, Martin;
- Alemany, Ramon;
- Gerritsen, Winald R.
Publication type:
Abstract
9. Coronaviruses: Development of Novel Oncolytic Vectors
Published in:
2005
By:
- Würdinger, Tom;
- Verheije, Hélène M.;
- van Beusechem, Victor W.;
- de Haan, Xander A.M.;
- Gerritsen, Winald R.;
- Rottier, Peter J.M.
Publication type:
Abstract
The Organotypic Multicellular Spheroid Is a Relevant Three-Dimensional Model to Study Adenovirus Replication and Penetration in Human Tumors in Vitro
Published in:
Molecular Therapy, 2002, v. 6, n. 5, p. 609, doi. 10.1006/mthe.2002.0713
By:
- Grill, Jacques;
- Lamfers, Martine L. M.;
- van Beusechem, Victor W.;
- Dirven, Clemens M.;
- Pherai, D. Shareen;
- Kater, Mathijs;
- Van der Valk, Paul;
- Vogels, Ronald;
- Vandertop, W. Peter;
- Pinedo, Herbert M.;
- Curiel, David T.;
- Gerritsen, Winald R.
Publication type:
Article
Double-Stranded RNA Structural Elements Holding the Key to Translational Regulation in Cancer: The Case of Editing in RNA-Binding Motif Protein 8A.
Published in:
Cells (2073-4409), 2021, v. 10, n. 12, p. 3543, doi. 10.3390/cells10123543
By:
- Abukar, Asra;
- Wipplinger, Martin;
- Hariharan, Ananya;
- Sun, Suna;
- Ronner, Manuel;
- Sculco, Marika;
- Okonska, Agata;
- Kresoja-Rakic, Jelena;
- Rehrauer, Hubert;
- Qi, Weihong;
- van Beusechem, Victor W.;
- Felley-Bosco, Emanuela
Publication type:
Article
Unleashing the Full Potential of Oncolytic Adenoviruses against Cancer by Applying RNA Interference: The Force Awakens.
Published in:
Cells (2073-4409), 2018, v. 7, n. 12, p. 228, doi. 10.3390/cells7120228
By:
- Brachtlova, Tereza;
- van Beusechem, Victor W.
Publication type:
Article
Rscreenorm: normalization of CRISPR and siRNA screen data for more reproducible hit selection.
Published in:
BMC Bioinformatics, 2018, v. 19, n. 1, p. 1, doi. 10.1186/s12859-018-2306-z
By:
- Bachas, Costa;
- Hodzic, Jasmina;
- van der Mijn, Johannes C.;
- Stoepker, Chantal;
- Verheul, Henk M. W.;
- Wolthuis, Rob M. F.;
- Felley-Bosco, Emanuela;
- van Wieringen, Wessel N.;
- van Beusechem, Victor W.;
- Brakenhoff, Ruud H.;
- de Menezes, Renée X.
Publication type:
Article
Quantitative Virus-Associated RNA Detection to Monitor Oncolytic Adenovirus Replication.
Published in:
International Journal of Molecular Sciences, 2024, v. 25, n. 12, p. 6551, doi. 10.3390/ijms25126551
By:
- Brachtlova, Tereza;
- Li, Jing;
- van der Meulen-Muileman, Ida H.;
- Sluiter, Femke;
- von Meijenfeldt, Willem;
- Witte, Isabella;
- Massaar, Sanne;
- van den Oever, Ruben;
- de Vrij, Jeroen;
- van Beusechem, Victor W.
Publication type:
Article
Human Non-Small Cell Lung Cancer-Chicken Embryo Chorioallantoic Membrane Tumor Models for Experimental Cancer Treatments.
Published in:
International Journal of Molecular Sciences, 2023, v. 24, n. 20, p. 15425, doi. 10.3390/ijms242015425
By:
- Li, Jing;
- Brachtlova, Tereza;
- van der Meulen-Muileman, Ida H.;
- Kleerebezem, Stijn;
- Liu, Chang;
- Li, Peiyu;
- van Beusechem, Victor W.
Publication type:
Article
Genome-wide siRNA screens identify RBBP9 function as a potential target in Fanconi anaemia-deficient head-and-neck squamous cell carcinoma.
Published in:
Communications Biology, 2023, v. 6, n. 1, p. 1, doi. 10.1038/s42003-022-04389-3
By:
- Pai, Govind;
- Roohollahi, Khashayar;
- Rockx, Davy;
- de Jong, Yvonne;
- Stoepker, Chantal;
- Pennings, Charlotte;
- Rooimans, Martin;
- Vriend, Lianne;
- Piersma, Sander;
- Jimenez, Connie R.;
- De Menezes, Renee X.;
- Van Beusechem, Victor W.;
- Brakenhoff, Ruud H.;
- Te Riele, Hein;
- Wolthuis, Rob M. F.;
- Dorsman, Josephine C.
Publication type:
Article
Conditionally replicating adenoviruses as anticancer agents and ways to improve their efficacy.
Published in:
Journal of Experimental Therapeutics & Oncology, 2004, v. 4, n. 1, p. 37
By:
- Oosterhoff, Dinja;
- Van Beusechem, Victor W.
Publication type:
Article
Genetic correction of cultured T cells from an adenosine deaminase-deficient patient: Characteristics of non-transduced and transduced T cells.
Published in:
European Journal of Immunology, 1992, v. 22, n. 1, p. 63, doi. 10.1002/eji.1830220111
By:
- Braakman, Eric;
- Van Beusechem, Victor W.;
- Van Krimpen, Brigitte A.;
- Fischer, Alain;
- Bolhuis, Reinder L. H.;
- Valerio, Dinko
Publication type:
Article
Whole genome RNAi screens reveal a critical role of REV3 in coping with replication stress.
Published in:
Molecular Oncology, 2014, v. 8, n. 8, p. 1747, doi. 10.1016/j.molonc.2014.07.008
By:
- Kotov, Ilya N.;
- Siebring-van Olst, Ellen;
- Knobel, Philip A.;
- van der Meulen-Muileman, Ida H.;
- Felley-Bosco, Emanuela;
- van Beusechem, Victor W.;
- Smit, Egbert F.;
- Stahel, Rolf A.;
- Marti, Thomas M.
Publication type:
Article
WEE1 inhibition sensitizes osteosarcoma to radiotherapy.
Published in:
BMC Cancer, 2011, v. 11, n. 1, p. 156, doi. 10.1186/1471-2407-11-156
By:
- PosthumaDeBoer, Jantine;
- Würdinger, Thomas;
- Graat, Harm C. A.;
- Beusechem, Victor W. van;
- Helder, Marco N.;
- Royen, Barend J. van;
- Kaspers, Gertjan J. L.
Publication type:
Article

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