Works matching AU Colotti, Gianni
Results: 45
Inhibition of Leishmania infantum trypanothione reductase by diaryl sulfide derivatives.
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- Journal of Enzyme Inhibition & Medicinal Chemistry, 2017, v. 32, n. 1, p. 304, doi. 10.1080/14756366.2016.1250755
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- Article
Nose-to-brain selective drug delivery to glioma via ferritin-based nanovectors reduces tumor growth and improves survival rate.
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- Cell Death & Disease, 2024, v. 15, n. 4, p. 1, doi. 10.1038/s41419-024-06653-2
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Bcl-2 family inhibitors sensitize human cancer models to therapy.
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- Cell Death & Disease, 2023, v. 14, n. 7, p. 1, doi. 10.1038/s41419-023-05963-1
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- Article
Sorcin promotes cell proliferation, migration and invasion in cancer by regulating the EGF-dependent EGFR signaling pathways.
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- Italian Journal of Anatomy & Embryology / Archivio Italiano di Anatomia Ed Embriologia, 2022, v. 126, p. 262
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Regulation of the EGFR endocytic route by an Endoplasmic Reticulum-related Ca<sup>2+</sup> binding protein.
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- Italian Journal of Anatomy & Embryology / Archivio Italiano di Anatomia Ed Embriologia, 2021, v. 125, p. 154
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- Article
Molecular basis for the impaired function of the natural F112L sorcin mutant: X-ray crystal structure, calcium affinity, and interaction with annexin VII and the ryanodine receptor.
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- FASEB Journal, 2008, v. 22, n. 1, p. 295, doi. 10.1096/fj.07-8988com
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Complex modulation of L-type Ca<sup>2+</sup> current inactivation by sorcin in isolated rabbit cardiomyocytes.
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- Pflügers Archiv: European Journal of Physiology, 2009, v. 457, n. 5, p. 1049, doi. 10.1007/s00424-008-0575-5
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Huntingtin Ubiquitination Mechanisms and Novel Possible Therapies to Decrease the Toxic Effects of Mutated Huntingtin.
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- Journal of Personalized Medicine, 2021, v. 11, n. 12, p. 1309, doi. 10.3390/jpm11121309
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Identification and binding mode of a novel Leishmania Trypanothione reductase inhibitor from high throughput screening.
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- PLoS Neglected Tropical Diseases, 2018, v. 12, n. 11, p. 1, doi. 10.1371/journal.pntd.0006969
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- Article
Spiro-containing derivatives show antiparasitic activity against Trypanosoma brucei through inhibition of the trypanothione reductase enzyme.
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- PLoS Neglected Tropical Diseases, 2020, p. 1, doi. 10.1371/journal.pntd.0008339
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- Article
Neuropilin‐1 is required for endothelial cell adhesion to soluble vascular endothelial growth factor receptor 1.
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- FEBS Journal, 2022, v. 289, n. 1, p. 183, doi. 10.1111/febs.16119
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- Article
Sorcin modulates cardiac L-type Ca<sup>2+</sup> current by functional interaction with the α<sub>1C</sub> subunit in rabbits.
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- Experimental Physiology, 2008, v. 93, n. 12, p. 1233, doi. 10.1113/expphysiol.2008.043497
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- Article
The Crystal Structures of the Tryparedoxin-Tryparedoxin Peroxidase Couple Unveil the Structural Determinants of Leishmania Detoxification Pathway.
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- PLoS Neglected Tropical Diseases, 2012, v. 6, n. 8, p. 1, doi. 10.1371/journal.pntd.0001781
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- Article
The Crystal Structures of the Tryparedoxin-Tryparedoxin Peroxidase Couple Unveil the Structural Determinants of Leishmania Detoxification Pathway.
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- PLoS Neglected Tropical Diseases, 2012, v. 6, n. 8, p. 1, doi. 10.1371/journal.pntd.0001781
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Exogenous peptides are able to penetrate human cell and mitochondrial membranes, stabilize mitochondrial tRNA structures, and rescue severe mitochondrial defects.
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- FASEB Journal, 2020, v. 34, n. 6, p. 7675, doi. 10.1096/fj.201903270R
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GOLPH3 Is Essential for Contractile Ring Formation and Rab11 Localization to the Cleavage Site during Cytokinesis in <i>Drosophila melanogaster</i>.
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- PLoS Genetics, 2014, v. 10, n. 5, p. 1, doi. 10.1371/journal.pgen.1004305
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Structural basis of Sorcin-mediated calcium-dependent signal transduction.
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- Scientific Reports, 2015, p. 16828, doi. 10.1038/srep16828
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Structure-based discovery of the first non-covalent inhibitors of Leishmania major tryparedoxin peroxidase by high throughput docking.
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- Scientific Reports, 2015, p. 9705, doi. 10.1038/srep09705
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Molecular characterization of nitrite reductase gene (aniA) and gene product in Neisseria meningitidis isolates: Is aniA essential for meningococcal survival?
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- IUBMB Life, 2008, v. 60, n. 9, p. 629, doi. 10.1002/iub.95
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EGF receptor in organ development, tissue homeostasis and regeneration.
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- Journal of Biomedical Science, 2025, v. 32, n. 1, p. 1, doi. 10.1186/s12929-025-01119-9
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- Article
Metal-Based Compounds as Prospective Antileishmanial Agents: Inhibition of Trypanothione Reductase by Selected Gold Complexes.
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- ChemMedChem, 2013, v. 8, n. 10, p. 1634, doi. 10.1002/cmdc.201300276
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Inhibition of Leishmania infantum Trypanothione Reductase by Azole-Based Compounds: a Comparative Analysis with Its Physiological Substrate by X-ray Crystallography.
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- ChemMedChem, 2013, v. 8, n. 7, p. 1175, doi. 10.1002/cmdc.201300176
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Investigation of the Entry Pathway and Molecular Nature of σ1 Receptor Ligands.
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- International Journal of Molecular Sciences, 2023, v. 24, n. 7, p. 6367, doi. 10.3390/ijms24076367
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Known Drugs Identified by Structure-Based Virtual Screening Are Able to Bind Sigma-1 Receptor and Increase Growth of Huntington Disease Patient-Derived Cells.
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- International Journal of Molecular Sciences, 2021, v. 22, n. 3, p. 1293, doi. 10.3390/ijms22031293
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- Article
Inhibition of Leishmania infantum Trypanothione Reductase by New Aminopropanone Derivatives Interacting with the NADPH Binding Site.
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- Molecules, 2023, v. 28, n. 1, p. 338, doi. 10.3390/molecules28010338
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- Article
Targeting Trypanothione Reductase, a Key Enzyme in the Redox Trypanosomatid Metabolism, to Develop New Drugs against Leishmaniasis and Trypanosomiases.
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- Molecules, 2020, v. 25, n. 8, p. 1924, doi. 10.3390/molecules25081924
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Small Molecule Inhibitors of KDM5 Histone Demethylases Increase the Radiosensitivity of Breast Cancer Cells Overexpressing JARID1B.
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- Molecules, 2019, v. 24, n. 9, p. 1739, doi. 10.3390/molecules24091739
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Sorcin, a Calcium Binding Protein Involved in the Multidrug Resistance Mechanisms in Cancer Cells.
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- Molecules, 2014, v. 19, n. 9, p. 13976, doi. 10.3390/molecules190913976
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The yeast penta-EF protein Pef1p is involved in cation-dependent budding and cell polarization.
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- Molecular Microbiology, 2007, v. 65, n. 4, p. 1122, doi. 10.1111/j.1365-2958.2007.05852.x
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The X-ray structure of N-methyltryptophan oxidase reveals the structural determinants of substrate specificity.
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- Proteins, 2008, v. 71, n. 4, p. 2065, doi. 10.1002/prot.21898
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Use of Ferritin-Based Metal-Encapsulated Nanocarriers as Anticancer Agents.
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- Applied Sciences (2076-3417), 2017, v. 7, n. 1, p. 101, doi. 10.3390/app7010101
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- Article
Short peptides from leucyl-tRNA synthetase rescue disease-causing mitochondrial tRNA point mutations.
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- Human Molecular Genetics, 2016, v. 25, n. 5, p. 903, doi. 10.1093/hmg/ddv619
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Sorcin in Cancer Development and Chemotherapeutic Drug Resistance.
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- Cancers, 2024, v. 16, n. 16, p. 2810, doi. 10.3390/cancers16162810
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Roles of Sorcin in Drug Resistance in Cancer: One Protein, Many Mechanisms, for a Novel Potential Anticancer Drug Target.
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- Cancers, 2020, v. 12, n. 4, p. 887, doi. 10.3390/cancers12040887
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Structure-guided approach to identify a novel class of anti-leishmaniasis diaryl sulfide compounds targeting the trypanothione metabolism.
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- Amino Acids, 2020, v. 52, n. 2, p. 247, doi. 10.1007/s00726-019-02731-4
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Glucose transportation in the brain and its impairment in Huntington disease: one more shade of the energetic metabolism failure?
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- Amino Acids, 2017, v. 49, n. 7, p. 1147, doi. 10.1007/s00726-017-2417-2
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- Article
A gold-containing drug against parasitic polyamine metabolism: the X-ray structure of trypanothione reductase from Leishmania infantum in complex with auranofin reveals a dual mechanism of enzyme inhibition.
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- Amino Acids, 2012, v. 42, n. 2/3, p. 803, doi. 10.1007/s00726-011-0997-9
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Polyamine metabolism in Leishmania: from arginine to trypanothione.
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- Amino Acids, 2011, v. 40, n. 2, p. 269, doi. 10.1007/s00726-010-0630-3
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- Article
The isolated carboxy-terminal domain of human mitochondrial leucyl-tRNA synthetase rescues the pathological phenotype of mitochondrial tRNA mutations in human cells.
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- EMBO Molecular Medicine, 2014, v. 6, n. 2, p. 169, doi. 10.1002/emmm.201303198
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Bioinformatics analysis of Ras homologue enriched in the striatum, a potential target for Huntington's disease therapy.
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- International Journal of Molecular Medicine, 2019, v. 44, n. 6, p. 2223, doi. 10.3892/ijmm.2019.4373
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- Article
ERp57 chaperon protein protects neuronal cells from Aβ‐induced toxicity.
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- Journal of Neurochemistry, 2022, v. 162, n. 4, p. 322, doi. 10.1111/jnc.15655
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Targeting the anti-apoptotic Bcl-2 family proteins: machine learning virtual screening and biological evaluation of new small molecules.
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- Theranostics, 2022, v. 12, n. 5, p. 2427, doi. 10.7150/thno.64233
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Sorcin Links Calcium Signaling to Vesicle Trafficking, Regulates Polo-Like Kinase 1 and Is Necessary for Mitosis.
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- PLoS ONE, 2014, v. 9, n. 1, p. 1, doi. 10.1371/journal.pone.0085438
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ESI MS Studies of T. Brucei Trypanothione Reductase and its Reactions With Selected Metal Compounds.
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- European Journal of Inorganic Chemistry, 2024, v. 27, n. 36, p. 1, doi. 10.1002/ejic.202400499
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Characterization of the Escherichia coli pyridoxal 5′‐phosphate homeostasis protein (YggS): Role of lysine residues in PLP binding and protein stability.
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- Protein Science: A Publication of the Protein Society, 2022, v. 31, n. 11, p. 1, doi. 10.1002/pro.4471
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