Works matching DE "HUNTINGTIN protein"
Results: 648
Endothelial Dysfunction in Huntington's Disease: Pathophysiology and Therapeutic Implications.
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- International Journal of Molecular Sciences, 2025, v. 26, n. 4, p. 1432, doi. 10.3390/ijms26041432
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Alkenyl oxindole is a novel PROTAC moiety that recruits the CRL4<sup>DCAF11</sup> E3 ubiquitin ligase complex for targeted protein degradation.
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- PLoS Biology, 2024, v. 22, n. 5, p. 1, doi. 10.1371/journal.pbio.3002550
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Targeting Pathogenic DNA and RNA Repeats: A Conceptual Therapeutic Way for Repeat Expansion Diseases.
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- Chemistry - A European Journal, 2022, v. 28, n. 54, p. 1, doi. 10.1002/chem.202201749
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Posttranslationally Acting Arginases Provide a Ribosomal Route to Non‐proteinogenic Ornithine Residues in Diverse Peptide Sequences.
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- Angewandte Chemie, 2020, v. 132, n. 48, p. 21626, doi. 10.1002/ange.202008990
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HAP1 helps to regulate actin-based transport of insulin-containing granules in pancreatic β cells.
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- Histochemistry & Cell Biology, 2015, v. 144, n. 1, p. 39, doi. 10.1007/s00418-015-1311-9
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Modulation of SETDB1 activity by APQ ameliorates heterochromatin condensation, motor function, and neuropathology in a Huntington's disease mouse model.
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- Journal of Enzyme Inhibition & Medicinal Chemistry, 2021, v. 36, n. 1, p. 856, doi. 10.1080/14756366.2021.1900160
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Selection and characterization of llama single domain antibodies against N-terminal huntingtin.
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- Neurological Sciences, 2015, v. 36, n. 3, p. 429, doi. 10.1007/s10072-014-1971-6
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Nuclear localization of huntingtin during spermatogenesis.
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- Neurological Sciences, 2014, v. 35, n. 3, p. 459, doi. 10.1007/s10072-013-1515-5
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Huntingtin-associated protein 1 regulates exocytosis, vesicle docking, readily releasable pool size and fusion pore stability in mouse chromaffin cells.
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- Journal of Physiology, 2014, v. 592, n. 7, p. 1505, doi. 10.1113/jphysiol.2013.268342
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Tonic mGluR5/CB1-dependent suppression of inhibition as a pathophysiological hallmark in the striatum of mice carrying a mutant form of huntingtin.
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- Journal of Physiology, 2013, v. 591, n. 4, p. 1145, doi. 10.1113/jphysiol.2012.241018
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Two novel DnaJ chaperone proteins CG5001 and P58IPK regulate the pathogenicity of Huntington's disease related aggregates.
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- Scientific Reports, 2024, v. 14, n. 1, p. 1, doi. 10.1038/s41598-024-71065-3
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Therapeutic Advances for Huntington's Disease.
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- Brain Sciences (2076-3425), 2020, v. 10, n. 1, p. 43, doi. 10.3390/brainsci10010043
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Monomeric, Oligomeric and Polymeric Proteins in Huntington Disease and Other Diseases of Polyglutamine Expansion.
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- Brain Sciences (2076-3425), 2014, v. 4, n. 1, p. 91, doi. 10.3390/brainsci4010091
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Altered Neuronal Dynamics in the Striatum on the Behavior of Huntingtin Interacting Protein 14 (HIP14) Knockout Mice.
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- Brain Sciences (2076-3425), 2013, v. 3, n. 4, p. 1588, doi. 10.3390/brainsci3041588
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Mitochondrial Quality Control via Mitochondrial Unfolded Protein Response (mtUPR) in Ageing and Neurodegenerative Diseases.
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- Biomolecules (2218-273X), 2023, v. 13, n. 12, p. 1789, doi. 10.3390/biom13121789
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Mesenchymal Stem Cell-Derived Extracellular Vesicles: An Emerging Diagnostic and Therapeutic Biomolecules for Neurodegenerative Disabilities.
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- Biomolecules (2218-273X), 2023, v. 13, n. 8, p. 1250, doi. 10.3390/biom13081250
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Large-Scale Integration of Single-Cell RNA-Seq Data Reveals Astrocyte Diversity and Transcriptomic Modules across Six Central Nervous System Disorders.
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- Biomolecules (2218-273X), 2023, v. 13, n. 4, p. 692, doi. 10.3390/biom13040692
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The Proteasome Activators Blm10/PA200 Enhance the Proteasomal Degradation of N-Terminal Huntingtin.
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- Biomolecules (2218-273X), 2020, v. 10, n. 11, p. 1581, doi. 10.3390/biom10111581
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Robust Cell-Free Expression of Sub-Pathological and Pathological Huntingtin Exon-1 for NMR Studies. General Approaches for the Isotopic Labeling of Low-Complexity Proteins.
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- Biomolecules (2218-273X), 2020, v. 10, n. 10, p. 1458, doi. 10.3390/biom10101458
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From Seeds to Fibrils and Back: Fragmentation as an Overlooked Step in the Propagation of Prions and Prion-Like Proteins.
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- Biomolecules (2218-273X), 2020, v. 10, n. 9, p. 1305, doi. 10.3390/biom10091305
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POSCAbilities: The Application of the Prion Organotypic Slice Culture Assay to Neurodegenerative Disease Research.
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- Biomolecules (2218-273X), 2020, v. 10, n. 7, p. 1079, doi. 10.3390/biom10071079
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Development of Fluorescent Turn-On Probes for CAG-RNA Repeats.
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- Biosensors (2079-6374), 2022, v. 12, n. 12, p. 1080, doi. 10.3390/bios12121080
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Effects of Stocking Density on the Growth Performance, Physiological Parameters, Antioxidant Status and Lipid Metabolism of Pelteobagrus fulvidraco in the Integrated Rice-Fish Farming System.
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- Animals (2076-2615), 2023, v. 13, n. 11, p. 1721, doi. 10.3390/ani13111721
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Abnormal outer and inner retina in a mouse model of Huntington's disease with age.
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- Frontiers in Aging Neuroscience, 2024, p. 1, doi. 10.3389/fnagi.2024.1434551
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Transplantation of human embryonic stem cells alleviates motor dysfunction in AAV2-Htt171-82Q transfected rat model of Huntington's disease.
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- Stem Cell Research & Therapy, 2021, v. 12, n. 1, p. 1, doi. 10.1186/s13287-021-02653-7
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miR-122 is upregulated upon htt-siRNA silencing in SH-SY5Y cell model of Huntington's disease.
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- Anatomy: International Journal of Experimental & Clinical Anatomy, 2022, v. 16, p. 283, doi. 10.2399/ana.22.003s
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Gangliosides as Therapeutic Targets for Neurodegenerative Diseases.
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- Journal of Lipids, 2024, v. 2024, p. 1, doi. 10.1155/2024/4530255
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Role of contactin-1 axonal glycoprotein and polyphenol in a mice model of friedreich ataxia.
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- Italian Journal of Anatomy & Embryology / Archivio Italiano di Anatomia Ed Embriologia, 2021, v. 125, p. 144
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PolyQ-independent toxicity associated with novel translational products from CAG repeat expansions.
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- PLoS ONE, 2020, v. 15, n. 4, p. 1, doi. 10.1371/journal.pone.0227464
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Association between IQ and FMR1 protein (FMRP) across the spectrum of CGG repeat expansions.
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- PLoS ONE, 2019, v. 14, n. 12, p. N.PAG, doi. 10.1371/journal.pone.0226811
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The interaction between RE1-silencing transcription factor (REST) and heat shock protein 90 as new therapeutic target against Huntington’s disease.
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- PLoS ONE, 2019, v. 14, n. 7, p. 1, doi. 10.1371/journal.pone.0220393
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Meso scale discovery-based assays for the detection of aggregated huntingtin.
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- PLoS ONE, 2019, v. 14, n. 3, p. 1, doi. 10.1371/journal.pone.0213521
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Huntingtin associates with the actin cytoskeleton and α-actinin isoforms to influence stimulus dependent morphology changes.
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- PLoS ONE, 2019, v. 14, n. 2, p. 1, doi. 10.1371/journal.pone.0212337
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PIN1 Modulates Huntingtin Levels and Aggregate Accumulation: An In vitro Model.
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- Frontiers in Cellular Neuroscience, 2017, v. 11, p. 1, doi. 10.3389/fncel.2017.00121
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Huntingtin Is Required for Neural But Not Cardiac/Pancreatic Progenitor Differentiation of Mouse Embryonic Stem Cells In vitro.
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- Frontiers in Cellular Neuroscience, 2017, v. 11, p. 1, doi. 10.3389/fncel.2017.00033
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The Generation of Mouse and Human Huntington Disease iPS Cells Suitable for In vitro Studies on Huntingtin Function.
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- Frontiers in Molecular Neuroscience, 2017, p. 1, doi. 10.3389/fnmol.2017.00253
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Huntingtin-Interacting Protein 1-Related Protein Plays a Critical Role in Dendritic Development and Excitatory Synapse Formation in Hippocampal Neurons.
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- Frontiers in Molecular Neuroscience, 2017, p. 1, doi. 10.3389/fnmol.2017.00186
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Loss of huntingtin-associated protein 1 impairs insulin secretion from pancreatic β-cells.
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- Cellular & Molecular Life Sciences, 2012, v. 69, n. 8, p. 1305, doi. 10.1007/s00018-011-0692-8
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Overlapping Role of SCYL1 and SCYL3 in Maintaining Motor Neuron Viability.
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- Journal of Neuroscience, 2018, v. 38, n. 10, p. 2615, doi. 10.1523/JNEUROSCI.2282-17.2018
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Mutant Huntingtin Inhibits αβ-Crystallin Expression and Impairs Exosome Secretion from Astrocytes.
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- Journal of Neuroscience, 2017, v. 37, n. 39, p. 9550, doi. 10.1523/JNEUROSCI.1418-17.2017
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Mutant Huntingtin Is Secreted via a Late Endosomal/Lysosomal Unconventional Secretory Pathway.
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- Journal of Neuroscience, 2017, v. 37, n. 37, p. 9000, doi. 10.1523/JNEUROSCI.0118-17.2017
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Mutant Huntingtin Impairs BDNF Release from Astrocytes by Disrupting Conversion of Rab3a-GTP into Rab3a-GDP.
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- Journal of Neuroscience, 2016, v. 36, n. 34, p. 8790, doi. 10.1523/JNEUROSCI.0168-16.2016
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Compartment-Dependent Degradation of Mutant Huntingtin Accounts for Its Preferential Accumulation in Neuronal Processes.
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- Journal of Neuroscience, 2016, v. 36, n. 32, p. 8317, doi. 10.1523/JNEUROSCI.0806-16.2016
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Enhanced Store-Operated Calcium Entry Leads to Striatal Synaptic Loss in a Huntington's Disease Mouse Model.
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- Journal of Neuroscience, 2016, v. 36, n. 1, p. 125, doi. 10.1523/JNEUROSCI.1038-15.2016
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Cortical Efferents Lacking Mutant huntingtin Improve Striatal Neuronal Activity and Behavior in a Conditional Mouse Model of Huntington's Disease.
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- Journal of Neuroscience, 2015, v. 35, n. 10, p. 4440, doi. 10.1523/JNEUROSCI.2812-14.2015
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Mutant Huntingtin Affects Cortical Progenitor Cell Division and Development of the Mouse Neocortex.
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- Journal of Neuroscience, 2014, v. 34, n. 30, p. 10034, doi. 10.1523/JNEUROSCI.0715-14.2014
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Huntingtin Is Required for Normal Excitatory Synapse Development in Cortical and Striatal Circuits.
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- Journal of Neuroscience, 2014, v. 34, n. 28, p. 9455, doi. 10.1523/JNEUROSCI.4699-13.2014
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Ubiquitin-Activating Enzyme Activity Contributes to Differential Accumulation of Mutant Huntingtin in Brain and Peripheral Tissues.
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- Journal of Neuroscience, 2014, v. 34, n. 25, p. 8411, doi. 10.1523/JNEUROSCI.0775-14.2014
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The Regulation of Autophagosome Dynamics by Huntingtin and HAP1 Is Disrupted by Expression of Mutant Huntingtin, Leading to Defective Cargo Degradation.
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- Journal of Neuroscience, 2014, v. 34, n. 4, p. 1293, doi. 10.1523/JNEUROSCI.1870-13.2014
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A Novel Hap1-Tsc1 Interaction Regulates Neuronal mTORC1 Signaling and Morphogenesis in the Brain.
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- Journal of Neuroscience, 2013, v. 33, n. 46, p. 18015, doi. 10.1523/JNEUROSCI.2290-13.2013
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