Works matching DE "FARNESYLTRANSFERASE"

Results: 45

Increased susceptibility to oxidative stress- and ultraviolet A-induced apoptosis in fibroblasts in atypical progeroid syndrome/atypical Werner syndrome with LMNA mutation.

Published in:

Experimental Dermatology, 2016, v. 25, p. 20, doi. 10.1111/exd.13086

By:

Motegi, Sei‐ichiro;
Uchiyama, Akihiko;
Yamada, Kazuya;
Ogino, Sachiko;
Yokoyama, Yoko;
Perera, Buddhini;
Takeuchi, Yuko;
Ishikawa, Osamu

Publication type:

Article

Transformation by Hras<sup>G12V</sup> is consistently associated with mutant allele copy gains and is reversed by farnesyl transferase inhibition.

Published in:

Oncogene, 2014, v. 33, n. 47, p. 5442, doi. 10.1038/onc.2013.489

By:

Chen, X;
Makarewicz, J M;
Knauf, J A;
Johnson, L K;
Fagin, J A

Publication type:

Article

Synthesis and biological evaluation of a new class of triazin-triazoles as potential inhibitors of human farnesyltransferase.

Published in:

Research on Chemical Intermediates, 2016, v. 42, n. 3, p. 1999, doi. 10.1007/s11164-015-2131-1

By:

Lucescu, Liliana;
Bîcu, Elena;
Belei, Dalila;
Shova, Sergiu;
Rigo, Benoît;
Gautret, Philippe;
Dubois, Joëlle;
Ghinet, Alina

Publication type:

Article

The Aspergillus fumigatus farnesyltransferase Ś-subunit, RamA, mediates growth, virulence, and antifungal susceptibility.

Published in:

Virulence, 2017, v. 8, n. 7, p. 1401, doi. 10.1080/21505594.2017.1328343

By:

Norton, Tiffany S.;
Al Abdallah, Qusai;
Hill, Amy M.;
Lovingood, Rachel V.;
Fortwendel, Jarrod R.

Publication type:

Article

Phase II study of the farnesyltransferase inhibitor R115777 in advanced melanoma (CALGB 500104).

Published in:

Journal of Translational Medicine, 2012, v. 10, n. 1, p. 246, doi. 10.1186/1479-5876-10-246

By:

Gajewski, Thomas F.;
Salama, April K. S.;
Niedzwiecki, Donna;
Johnson, Jeffrey;
Linette, Gerald;
Bucher, Cynthia;
Blaskovich, Michelle A.;
Sebti, Said M.;
Haluska, Frank

Publication type:

Article

Toxic effects of phytol and retinol on human glioblastoma cells are associated with modulation of cholesterol and fatty acid biosynthetic pathways.

Published in:

Journal of Neuro-Oncology, 2018, v. 136, n. 3, p. 435, doi. 10.1007/s11060-017-2672-9

By:

Facchini, Gustavo;
Ignarro, Raffaela Silvestre;
Rodrigues-Silva, Erika;
Vieira, André Schwambach;
Lopes-Cendes, Iscia;
Castilho, Roger Frigério;
Rogerio, Fabio

Publication type:

Article

Probing the function of protein farnesyltransferase in Tripterygium wilfordii.

Published in:

Plant Cell Reports, 2019, v. 38, n. 2, p. 211, doi. 10.1007/s00299-018-2363-9

By:

Su, Ping;
Gao, Linhui;
Liu, Shuang;
Guan, Hongyu;
Wang, Jian;
Zhang, Yifeng;
Zhao, Yujun;
Hu, Tianyuan;
Tu, Lichan;
Zhou, Jiawei;
Ma, Baowei;
Liu, Xihong;
Huang, Luqi;
Gao, Wei

Publication type:

Article

Maximization of Extracellular Ftase Production by Aspergillus stallus through Batch Fermentation Using Food Grade Sucrose as Substrate.

Published in:

Journal of Ravishankar University, Part-B Science, 2016, v. 29, p. 122

By:

Belorkar, Seema A.;
Gupta, A. K.;
Rai, Vibhuti

Publication type:

Article

THE EFFECTS OF FARNESYLTRANSFERASE INHIBITOR L-744,832 AND RADIOTHERAPY ON H-RAS + (SVR A221A) CELL LINE.

Published in:

Nobel Medicus Journal, 2012, v. 8, n. 3, p. 76

By:

Özdemir, Feyyaz;
Kavgacı, Halil;
Ovalı, Ercüment;
Yılmaz, Mustafa;
Yıldız, Bülent;
Aydın, Fazıl

Publication type:

Article

Evolutionary comparison of prenylation pathway in kinetoplastid Leishmania and its sister Leptomonas.

Published in:

BMC Evolutionary Biology, 2015, v. 15, p. 1, doi. 10.1186/s12862-015-0538-3

By:

Chauhan, Indira Singh;
Kaur, Jaspreet;
Krishna, Shagun;
Ghosh, Arpita;
Singh, Prashant;
Siddiqi, Mohammad Imran;
Singh, Neeloo

Publication type:

Article

Combined p21-activated kinase and farnesyltransferase inhibitor treatment exhibits enhanced anti-proliferative activity on melanoma, colon and lung cancer cell lines.

Published in:

Molecular Cancer, 2013, v. 12, n. 1, p. 1, doi. 10.1186/1476-4598-12-88

By:

Porcu, Giampiero;
Parsons, Ainslie B.;
Giandomenico, Daniele Di;
Lucisano, Giuseppe;
Mosca, Maria Giovanna;
Boone, Charles;
Ragnini-Wilson, Antonella

Publication type:

Article

IADE: a system for intelligent automatic design of bioisosteric analogs.

Published in:

Journal of Computer-Aided Molecular Design, 2012, v. 26, n. 11, p. 1207, doi. 10.1007/s10822-012-9609-3

By:

Ertl, Peter;
Lewis, Richard

Publication type:

Article

Tipifarnib-mediated suppression of T-bet-dependent signaling pathways.

Published in:

Cancer Immunology, Immunotherapy, 2012, v. 61, n. 4, p. 523, doi. 10.1007/s00262-011-1109-0

By:

Bai, Fanqi;
Villagra, Alejandro;
Zou, JianXiang;
Painter, Jeffrey;
Connolly, Kirby;
Blaskovich, Michelle;
Sokol, Lubomir;
Sebti, Said;
Djeu, Julie;
Loughran, Thomas;
Wei, Sheng;
Sotomayor, Eduardo;
Epling-Burnette, Pearlie

Publication type:

Article

Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity.

Published in:

Nature, 2012, v. 485, n. 7399, p. 517, doi. 10.1038/nature11007

By:

Fünfschilling, Ursula;
Supplie, Lotti M.;
Mahad, Don;
Boretius, Susann;
Saab, Aiman S.;
Edgar, Julia;
Brinkmann, Bastian G.;
Kassmann, Celia M.;
Tzvetanova, Iva D.;
Möbius, Wiebke;
Diaz, Francisca;
Meijer, Dies;
Suter, Ueli;
Hamprecht, Bernd;
Sereda, Michael W.;
Moraes, Carlos T.;
Frahm, Jens;
Goebbels, Sandra;
Nave, Klaus-Armin

Publication type:

Article

A Farnesyltransferase Acts to Inhibit Ectopic Neurite Formation in C. elegans.

Published in:

PLoS ONE, 2016, v. 11, n. 6, p. 1, doi. 10.1371/journal.pone.0157537

By:

Carr, David;
Sanchez-Alvarez, Leticia;
Imai, Janice H.;
Slatculescu, Cristina;
Noblett, Nathaniel;
Mao, Lei;
Beese, Lorena;
Colavita, Antonio

Publication type:

Article

Site-Specific Labeling of Proteins and Peptides with Trans-cyclooctene Containing Handles Capable of Tetrazine Ligation.

Published in:

Chemical Biology & Drug Design, 2014, v. 84, n. 2, p. 140, doi. 10.1111/cbdd.12303

By:

Wollack, James W.;
Monson, Benjamin J.;
Dozier, Jonathan K.;
Dalluge, Joseph J.;
Poss, Kristina;
Hilderbrand, Scott A.;
Distefano, Mark D.

Publication type:

Article

Progeria: A rare genetic premature ageing disorder.

Published in:

Indian Journal of Medical Research, 2014, v. 139, n. 5, p. 667

By:

Sinha, Jitendra Kumar;
Ghosh, Shampa;
Raghunath, Manchala

Publication type:

Article

Stimulating Effect of Manumycin A on Suicidal Erythrocyte Death.

Published in:

Cellular Physiology & Biochemistry (Karger AG), 2016, v. 38, n. 5, p. 1147, doi. 10.1159/000443065

By:

Egler, Jasmin;
Zierle, Jens;
Lang, Florian

Publication type:

Article

Inhibition of GGTase-I and FTase disrupts cytoskeletal organization of human PC-3 prostate cancer cells.

Published in:

Cell Biology International, 2010, v. 34, n. 8, p. 815, doi. 10.1042/CBI20090288

By:

Virtanen, Sanna S.;
Sandholm, Jouko;
Yegutkin, Gennady;
Väänänen, H. Kalervo;
Härkönen, Pirkko L.

Publication type:

Article

Farnesyl transferase inhibitor FTI-277 inhibits breast cell invasion and migration by blocking H-Ras activation.

Published in:

Oncology Letters, 2016, v. 12, n. 3, p. 2222, doi. 10.3892/ol.2016.4837

By:

KYUNG HUN LEE;
MINSOO KOH;
AREE MOON

Publication type:

Article

Absence of Protoheme IX Farnesyltransferase CtaB Causes Virulence Attenuation but Enhances Pigment Production and Persister Survival in MRSA.

Published in:

Frontiers in Microbiology, 2016, v. 7, p. 1, doi. 10.3389/fmicb.2016.01625

By:

Tao Xu;
Jia Zhang;
Jiazhen Chen;
Nan Wu;
Wenhong Zhang;
Ying Zhang;
Jian Han;
Von Wright, Atte;
Sriramulu, Dinesh

Publication type:

Article

Farnesyltransferase inhibitor FTI-277 inhibits PD-L1 expression on septic spleen lymphocytes and promotes spleen lymphocyte activation.

Published in:

Clinical & Experimental Immunology, 2017, v. 190, n. 1, p. 8, doi. 10.1111/cei.12995

By:

Li, W.;
Tu, J.;
Liu, X.;
Yang, W.

Publication type:

Article

Phase 1/1b study of lonafarnib and temozolomide in patients with recurrent or temozolomide refractory glioblastoma.

Published in:

Cancer (0008543X), 2013, v. 119, n. 15, p. 2747, doi. 10.1002/cncr.28031

By:

Yust‐Katz, Shlomit;
Liu, Diane;
Yuan, Ying;
Liu, Vivien;
Kang, Sanghee;
Groves, Morris;
Puduvalli, Vinay;
Levin, Victor;
Conrad, Charles;
Colman, Howard;
Hsu, Sigmonid;
Yung, W. K. Alfred;
Gilbert, Mark R.

Publication type:

Article

Sensing Enzymatic Activity by Exposure and Selection of DNA-Encoded Probes.

Published in:

Angewandte Chemie, 2016, v. 128, n. 33, p. 9714, doi. 10.1002/ange.201603387

By:

Jetson, Rachael R.;
Krusemark, Casey J.

Publication type:

Article

Identification of tipifarnib sensitivity biomarkers in T-cell acute lymphoblastic leukemia and T-cell lymphoma.

Published in:

Scientific Reports, 2020, v. 10, n. 1, p. 1, doi. 10.1038/s41598-020-63434-5

By:

Alonso-Alonso, Ruth;
Mondéjar, Rufino;
Martínez, Nerea;
García-Diaz, Nuria;
Pérez, Cristina;
Merino, David;
Rodríguez, Marta;
Esteve-Codina, Anna;
Fuste, Berta;
Gut, Marta;
Burrows, Francis;
Scholz, Catherine;
Vaqué, Jose Pedro;
Gualberto, Antonio;
Piris, Miguel Ángel

Publication type:

Article

A farnesyltransferase inhibitor activates lysosomes and reduces tau pathology in mice with tauopathy.

Published in:

Science Translational Medicine, 2019, v. 11, n. 485, p. N.PAG, doi. 10.1126/scitranslmed.aat3005

By:

Hernandez, Israel;
Luna, Gabriel;
Rauch, Jennifer N.;
Giroux, Michel;
Boctor, Daniel;
Sibih, Youssef E.;
Kang, Alexander A.;
Hinman, Cassidy R.;
Cerovac, Vesna;
Guzman, Elmer;
Zhou, Honjun;
Fisher, Steven K.;
Kosik, Kenneth S.;
Reis, Surya A.;
Haggarty, Stephen J.;
Karch, Celeste M.;
Storm, Nadia J.;
Diaz, Antonio;
Kaushik, Susmita;
Cuervo, Ana M.

Publication type:

Article

In vitro antifungal activity of farnesyltransferase inhibitors against clinical isolates of Aspergillus and Candida.

Published in:

Annals of Clinical Microbiology & Antimicrobials, 2013, v. 12, n. 1, p. 1, doi. 10.1186/1476-0711-12-37

By:

Jianjun Qiao;
Peiping Gao;
Xiaoling Jiang;
Hong Fang

Publication type:

Article

The FNTB promoter polymorphism rs11623866 as a potential predictive biomarker for lonafarnib treatment of ovarian cancer patients.

Published in:

British Journal of Clinical Pharmacology, 2015, v. 80, n. 5, p. 1139, doi. 10.1111/bcp.12688

By:

Bachmann, Hagen Sjard;
Meier, Werner;
Bois, Andreas;
Kimmig, Rainer;
Kuhlmann, Jan Dominik;
Siffert, Winfried;
Sehouli, Jalid;
Wollschlaeger, Kerstin;
Huober, Jens;
Hillemanns, Peter;
Burges, Alexander;
Schmalfeldt, Barbara;
Aminossadati, Behnaz;
Wimberger, Pauline

Publication type:

Article

Dysregulation of astrocyte extracellular signaling in Costello syndrome.

Published in:

Science Translational Medicine, 2015, v. 7, n. 286, p. 1, doi. 10.1126/scitranslmed.aaa5645

By:

Krencik, Robert;
Hokanson, Kenton C.;
Narayan, Aditi R.;
Dvornik, Jill;
Rooney, Gemma E.;
Rauen, Katherine A.;
Weiss, Lauren A.;
Rowitch, David H.;
Ullian, Erik M.

Publication type:

Article

The addition of the farnesyl transferase inhibitor, tipifarnib, to low dose cytarabine does not improve outcome for older patients with AML.

Published in:

British Journal of Haematology, 2012, v. 158, n. 4, p. 519, doi. 10.1111/j.1365-2141.2012.09165.x

By:

Burnett, Alan K.;
Russell, Nigel H.;
Culligan, Dominic;
Cavanagh, Jamie;
Kell, Jonathan;
Wheatley, Keith;
Virchis, Andra;
Hills, Robert K.;
Milligan, Donald

Publication type:

Article

Progeria: case report and new drugs perspectives.

Published in:

2018

By:

Grana, A. G.;
Silva, A. A.;
Moura Filho, F. R.;
Rodrigues Ferreira Rocha De Alencar, R.;
Chicre Bandeira De Melo, P.

Publication type:

Case Study

Cytoprotective effect of the small GTPase RhoB expressed upon treatment of fibroblasts with the Ras-glucosylating Clostridium sordellii lethal toxin

Published in:

FEBS Letters, 2012, v. 586, n. 20, p. 3665, doi. 10.1016/j.febslet.2012.08.024

By:

Huelsenbeck, Johannes;
May, Martin;
Schulz, Florian;
Schelle, Ilona;
Ronkina, Natalia;
Hohenegger, Martin;
Fritz, Gerhard;
Just, Ingo;
Gerhard, Ralf;
Genth, Harald

Publication type:

Article

Altered chromatin organization and SUN2 localization in mandibuloacral dysplasia are rescued by drug treatment.

Published in:

Histochemistry & Cell Biology, 2012, v. 138, n. 4, p. 643, doi. 10.1007/s00418-012-0977-5

By:

Camozzi, Daria;
D'Apice, Maria;
Schena, Elisa;
Cenni, Vittoria;
Columbaro, Marta;
Capanni, Cristina;
Maraldi, Nadir;
Squarzoni, Stefano;
Ortolani, Michela;
Novelli, Giuseppe;
Lattanzi, Giovanna

Publication type:

Article

Precision Medicine and Progress in the Treatment of Hutchinson-Gilford Progeria Syndrome.

Published in:

2018

By:

Hisama, Fuki Marie;
Oshima, Junko

Publication type:

Editorial

Mutagenesis and biochemical studies on AuaA confirmed the importance of the two conserved aspartate-rich motifs and suggested difference in the amino acids for substrate binding in membrane-bound prenyltransferases.

Published in:

Archives of Microbiology, 2012, v. 194, n. 7, p. 589, doi. 10.1007/s00203-012-0795-0

By:

Stec, Edyta;
Li, Shu-Ming

Publication type:

Article

Molecular dynamic simulations and structure-based pharmacophore development for farnesyltransferase inhibitors discovery.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2016, v. 31, n. 6, p. 1428, doi. 10.3109/14756366.2016.1144593

By:

Moorthy, N. S. Hari Narayana;
Sousa, Sergio F.;
Ramos, Maria J.;
Fernandes, Pedro A.

Publication type:

Article

New protein farnesyltransferase inhibitors in the 3-arylthiophene 2-carboxylic acid series: diversification of the aryl moiety by solid-phase synthesis.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2013, v. 28, n. 1, p. 163, doi. 10.3109/14756366.2011.643302

By:

Lethu, Sébastien;
Bosc, Damien;
Mouray, Elisabeth;
Grellier, Philippe;
Dubois, Joëlle

Publication type:

Article

Loss of protohaem IX farnesyltransferase in mature dentate granule cells impairs short-term facilitation at mossy fibre to CA3 pyramidal cell synapses.

Published in:

Journal of Physiology, 2017, v. 595, n. 6, p. 2147, doi. 10.1113/JP273581

By:

Booker, Sam A.;
Campbell, Graham R.;
Mysiak, Karolina S.;
Brophy, Peter J.;
Kind, Peter C.;
Mahad, Don J.;
Wyllie, David J. A.

Publication type:

Article

Tipifarnib and tanespimycin show synergic proapoptotic activity in U937 cells.

Published in:

Journal of Cancer Research & Clinical Oncology, 2012, v. 138, n. 3, p. 537, doi. 10.1007/s00432-011-1131-9

By:

Krzykowska-Petitjean, Katarzyna;
Małecki, Jędrzej;
Bentke, Anna;
Ostrowska, Barbara;
Laidler, Piotr

Publication type:

Article

Effect of Farnesyltransferase Inhibitor R115777 on Mitochondria of Plasmodium falciparum.

Published in:

Korean Journal of Parasitology, 2015, v. 53, n. 4, p. 421, doi. 10.3347/kjp.2015.53.4.421

By:

Young Ran Ha;
Bae-Geun Hwang;
Yeonchul Hong;
Hye-Won Yang;
Sang Joon Lee

Publication type:

Article

Farnesyltransferase inhibitors prevent HIV protease inhibitor (lopinavir/ritonavir)-induced lipodystrophy and metabolic syndrome in mice.

Published in:

Experimental & Therapeutic Medicine, 2018, v. 15, n. 2, p. 1314, doi. 10.3892/etm.2017.5526

By:

Tanaka, Tomokazu;
Nakazawa, Harumasa;
Kuriyama, Naohide;
Kaneki, Masao

Publication type:

Article

Farnesyltransferase Inhibitor Manumycin Targets IL1β-Ras-HIF-1α Axis in Tumor Cells of Diverse Origin.

Published in:

Inflammation, 2012, v. 35, n. 2, p. 516, doi. 10.1007/s10753-011-9340-6

By:

Sharma, Vivek;
Shaheen, Sk.;
Dixit, Deobrat;
Sen, Ellora

Publication type:

Article

Progeria drug trial promising.

Published in:: Australian Journal of Pharmacy, 2012, v. 93, n. 1110, p. 50
Publication type:: Article

Molecular dynamics analysis of a series of 22 potential farnesyltransferase substrates containing a CaaX-motif.

Published in:

Journal of Molecular Modeling, 2013, v. 19, n. 2, p. 673, doi. 10.1007/s00894-012-1590-1

By:

Sousa, Sérgio;
Coimbra, João;
Paramos, Diogo;
Pinto, Rita;
Guimarães, Rodrigo;
Teixeira, Vitor;
Fernandes, Pedro;
Ramos, Maria

Publication type:

Article

Effect of farnesyltransferase inhibitor on the function of mitochondria of Plasmodium falciparum.

Published in:

2012

By:

Young Ran Ha;
Sang Joon Lee

Publication type:

Abstract