Works matching AU Zhimin Zhai

Results: 84

Outcomes of Second Anti-CD19 CAR T-Cell Therapy (CART2) in Acute B Lymphoblastic Leukemia and the Impact of Allo-HSCT on Efficacy.

Published in:

Cell Transplantation, 2023, v. 32, p. 1, doi. 10.1177/09636897231204724

By:

Xu, Qianwen;
Shi, Yi;
Xue, Lei;
An, Furun;
Xu, Hui;
Liu, Xin;
Zhu, Xiaoyu;
Sun, Zimin;
Zhai, Zhimin;
Wang, Xingbing

Publication type:

Article

Elevated circulating myeloid‐derived suppressor cells associated with poor prognosis in B‐cell non‐Hodgkin's lymphoma patients.

Published in:

Immunity, Inflammation & Disease, 2022, v. 10, n. 5, p. 1, doi. 10.1002/iid3.616

By:

Wang, Yangyang;
Wang, Jiyu;
Zhu, Fengfeng;
Wang, Huiping;
Yi, Liuying;
Huang, Keke;
Zhai, Zhimin

Publication type:

Article

Stress‐induced premature senescence activated by the SENEX gene mediates apoptosis resistance of diffuse large B‐cell lymphoma via promoting immunosuppressive cells and cytokines.

Published in:

Immunity, Inflammation & Disease, 2020, v. 8, n. 4, p. 672, doi. 10.1002/iid3.356

By:

Wang, Jiyu;
Tao, Qianshan;
Pan, Ying;
Wanyan, Zhixiang;
Zhu, Fengfeng;
Xu, Xuanxuan;
Wang, Huiping;
Yi, Liuying;
Zhou, Mei;
Zhai, Zhimin

Publication type:

Article

The function of T cells in immune thrombocytopenia.

Published in:

2025

By:

Bu, Siyuan;
Liu, Min;
Yang, Lu;
Lee, Pamela;
Miller, Heather;
Park, Chan-Sik;
Byazrova, Maria;
Filatov, Alexander;
Benlagha, Kamel;
Gaber, Timo;
Buttgereit, Frank;
Gong, Quan;
Zhai, Zhimin;
Liu, Chaohong

Publication type:

Literature Review

Novel link between E2F1 and Smac/DIABLO: proapoptotic Smac/DIABLO is transcriptionally upregulated by E2F1.

Published in:

Nucleic Acids Research, 2006, v. 34, n. 7, p. 2046, doi. 10.1093/nar/gkl150

By:

Xie, Wei;
Jiang, Peng;
Miao, Lin;
Zhao, Ying;
Zhimin, Zhai;
Qing, Li;
Zhu, Wei-guo;
Wu, Mian

Publication type:

Article

Association of immunosuppressive CD45+CD33+CD14− CD10−HLA-DR−/low neutrophils with poor prognosis in patients with lymphoma and their expansion and activation through STAT3/arginase-1 pathway in vitro

Published in:

CytoJournal, 2024, v. 21, p. 1, doi. 10.25259/Cytojournal_165_2024

By:

Xiao, Meng;
Zhou, Ji;
Zhang, Wanqiu;
Ding, Yangyang;
Guo, Jinjing;
Liang, Xue;
Zhu, Jinli;
Jiao, Xunyi;
Zhai, Zhimin;
Wang, Huiping

Publication type:

Article

Down-regulation of BCL2L13 renders poor prognosis in clear cell and papillary renal cell carcinoma.

Published in:

Cancer Cell International, 2021, v. 21, n. 1, p. 1, doi. 10.1186/s12935-021-02039-y

By:

Meng, Fei;
Zhang, Luojin;
Zhang, Mingjun;
Ye, Kaiqin;
Guo, Wei;
Liu, Yu;
Yang, Wulin;
Zhai, Zhimin;
Wang, Hongzhi;
Xiao, Jun;
Dai, Haiming

Publication type:

Article

Cyclic thrombocytopenia associated with estradiol: a case report.

Published in:

Hematology, 2023, v. 28, n. 1, p. 1, doi. 10.1080/16078454.2023.2240140

By:

Pang, Ningbo;
Li, Yingwei;
Zhou, Kangxi;
Liu, Chunliang;
Yan, Rong;
Sun, Chenglin;
Xiao, Weiling;
Ruan, Changgeng;
Zhai, Zhimin;
Dai, Kesheng

Publication type:

Article

Immune dysregulation in primary immune thrombocytopenia patients.

Published in:

Hematology, 2018, v. 23, n. 8, p. 510, doi. 10.1080/10245332.2018.1435021

By:

Zhang, Jiakui;
Zhang, Qiuye;
Li, Yingwei;
Tao, Lili;
Wu, Fan;
Shen, Yuanyuan;
Tao, Qianshan;
Xu, Xuanxuan;
Wu, Can;
Ruan, Yanjie;
Wang, Jiyu;
Wang, Jeffrey;
Wang, Yiping;
Zhai, Zhimin

Publication type:

Article

Relationship between JAK2V617F mutation, allele burden and coagulation function in Ph-negative myeloproliferative neoplasms.

Published in:

Hematology, 2017, v. 22, n. 6, p. 354, doi. 10.1080/10245332.2016.1267830

By:

Hu, Linhui;
Pu, Lianfang;
Ding, Yangyang;
Li, Manman;
Cabanero, Michael;
Xie, Jingxin;
Zhou, Dejun;
Yang, Dongdong;
Zhang, Cui;
Wang, Huiping;
Zhai, Zhimin;
Ru, Xiang;
Li, Jingrong;
Xiong, Shudao

Publication type:

Article

Circulating Monocytic Myeloid-Derived Suppressor Cells Are Elevated and Associated with Poor Prognosis in Acute Myeloid Leukemia.

Published in:

2020

By:

Wang, Huiping;
Tao, Qianshan;
Wang, Zhitao;
Zhang, Qing;
Xiao, Hao;
Zhou, Mei;
Dong, Yi;
Zhai, Zhimin

Publication type:

journal article

The characterization of CD8+ T-cell responses in COVID-19.

Published in:

Emerging Microbes & Infections, 2024, v. 13, n. 1, p. 1, doi. 10.1080/22221751.2023.2287118

By:

Yuanting Yang;
Miller, Heather;
Byazrova, Maria G.;
Cndotti, Fabio;
Benlagha, Kamel;
Saraiva Camara, Niels Olsen;
Junming Shi;
Huamei Forsman;
Lee, Pamela;
Lu Yang;
Filatov, Alexander;
Zhimin Zhai;
Chaohong Liu

Publication type:

Article

Case Report: Combined Intravenous Infusion and Local Injection of CAR-T Cells Induced Remission in a Relapsed Diffuse Large B-Cell Lymphoma Patient.

Published in:

Frontiers in Immunology, 2021, v. 11, p. N.PAG, doi. 10.3389/fimmu.2021.665230

By:

Hu, Linhui;
Wu, Fan;
Wang, Huiping;
Zhu, Weiwei;
Wang, Juan;
Yu, Fengxiang;
Zhai, Zhimin

Publication type:

Article

Prognostic value of combined WT1 and multiparameter flow cytometry assessment for measurable residual disease after induction in non-APL acute myeloid leukemia.

Published in:

Scandinavian Journal of Clinical & Laboratory Investigation, 2023, v. 83, n. 5, p. 340, doi. 10.1080/00365513.2023.2227946

By:

Ding, Yangyang;
Liu, Zelin;
Wang, Huiping;
Xiong, Shudao;
Zhai, Zhimin

Publication type:

Article

Chronic myeloid leukemia patients and treatment-free remission attitudes: a multicenter survey.

Published in:

Patient Preference & Adherence, 2018, v. 12, p. 1025, doi. 10.2147/PPA.S163393

By:

Lou, Jin;
Huang, Junjie;
Wang, Zitong;
Wen, Bingbing;
Tu, Chuanqing;
Huang, Wangxiang;
Zhai, Zhimin;
Du, Xin

Publication type:

Article

Predictive model for CAR‐T cell therapy success in patients with relapsed/refractory B‐cell acute lymphoblastic leukaemia.

Published in:

Scandinavian Journal of Immunology, 2024, v. 99, n. 4, p. 1, doi. 10.1111/sji.13352

By:

Pu, Lianfang;
Wang, Huiping;
Wu, Fan;
An, Furun;
Xiao, Hao;
Wang, Yangyang;
Liang, Xue;
Zhai, Zhimin

Publication type:

Article

The prognostic value of tumour‐associated macrophages in Non‐Hodgkin's lymphoma: A systematic review and meta‐analysis.

Published in:

Scandinavian Journal of Immunology, 2020, v. 91, n. 1, p. N.PAG, doi. 10.1111/sji.12814

By:

Xu, Xuanxuan;
Li, Zhixia;
Liu, Jun;
Zhu, Fengfeng;
Wang, Zhitao;
Wang, Jiyu;
Zhang, Jiakui;
Wang, Huiping;
Zhai, Zhimin

Publication type:

Article

Comparison of first-line treatments for elderly patients with diffuse large B-cell lymphoma: A systematic review and network meta-analysis.

Published in:

Frontiers in Immunology, 2023, v. 13, p. 01, doi. 10.3389/fimmu.2022.1082293

By:

Yangyang Wang;
Xiyang Ren;
Keke Huang;
Xue Liang;
Lianfang Pu;
Linhui Hu;
Zhimin Zhai

Publication type:

Article

Impact of Consolidative Unrelated Cord Blood Transplantation on Clinical Outcomes of Patients With Relapsed/Refractory Acute B Lymphoblastic Leukemia Entering Remission Following CD19 Chimeric Antigen Receptor T Cells.

Published in:

Frontiers in Immunology, 2022, v. 13, p. 1, doi. 10.3389/fimmu.2022.879030

By:

Xu, Qianwen;
Xue, Lei;
An, Furun;
Xu, Hui;
Wang, Li;
Geng, Liangquan;
Zhang, Xuhan;
Song, Kaidi;
Yao, Wen;
Wan, Xiang;
Tong, Juan;
Liu, Huilan;
Liu, Xin;
Zhu, Xiaoyu;
Zhai, Zhimin;
Sun, Zimin;
Wang, Xingbing

Publication type:

Article

Monocytic Myeloid-Derived Suppressor Cells But Not Monocytes Predict Poor Prognosis of Acute Myeloid Leukemia.

Published in:

Turkish Journal of Hematology, 2022, v. 39, n. 4, p. 230, doi. 10.4274/tjh.galenos.2022.2022.0137

By:

Xiyang Ren;
Qianshan Tao;
Huiping Wang;
Qing Zhang;
Mei Zhou;
Linlin Liu;
Zhimin Zhai

Publication type:

Article

Stress-Induced Premature Senescence Promotes Proliferation by Activating the SENEX and p16INK4a/Retinoblastoma (Rb) Pathway in Diffuse Large B-Cell Lymphoma.

Published in:

Turkish Journal of Hematology, 2019, v. 36, n. 4, p. 247, doi. 10.4274/tjh.galenos.2019.2019.0117

By:

Jiyu Wang;
Zhitao Wang;
Huiping Wang;
Zhixiang Wanyan;
Ying Pan;
Fengfeng Zhu;
Qianshan Tao;
Zhimin Zhai

Publication type:

Article

Idiopathic multicentric castleman's disease mimicking immunoglobulin G4-related disease responding well to Bortezomib: a case report.

Published in:

2023

By:

Peng, Qian;
Wu, Fan;
Shi, Yuting;
Wang, Juan;
Zhai, Zhimin;
Wang, Zhitao

Publication type:

Case Study

A Bruton tyrosine kinase inhibitor-resistance gene signature predicts prognosis and identifies TRIP13 as a potential therapeutic target in diffuse large B-cell lymphoma.

Published in:

Scientific Reports, 2024, v. 14, n. 1, p. 1, doi. 10.1038/s41598-024-72121-8

By:

Ding, Yangyang;
Huang, Keke;
Sun, Cheng;
Liu, Zelin;
Zhu, Jinli;
Jiao, Xunyi;
Liao, Ya;
Feng, Xiangjiang;
Guo, Jingjing;
Zhu, Chunhua;
Zhai, Zhimin;
Xiong, Shudao

Publication type:

Article

Identification of a novel lactylation-related gene signature predicts the prognosis of multiple myeloma and experiment verification.

Published in:

Scientific Reports, 2024, v. 14, n. 1, p. 1, doi. 10.1038/s41598-024-65937-x

By:

Sun, Cheng;
Zhang, Wanqiu;
Liu, Hao;
Ding, Yangyang;
Guo, Jingjing;
Xiong, Shudao;
Zhai, Zhimin;
Hu, Wei

Publication type:

Article

Regulatory T cells-derived IL-35 promotes the growth of adult acute myeloid leukemia blasts.

Published in:

International Journal of Cancer, 2015, v. 137, n. 10, p. 2384, doi. 10.1002/ijc.29563

By:

Tao, Qianshan;
Pan, Ying;
Wang, Yiping;
Wang, Huiping;
Xiong, Shudao;
Li, Qing;
Wang, Jia;
Tao, Lili;
Wang, Zhitao;
Wu, Fan;
Zhang, Rui;
Zhai, Zhimin

Publication type:

Article

Hepatosplenic T‐Cell Lymphoma in an Immunocompetent Male with Central Nervous System Invasion: A Rare Clinical Entity.

Published in:

Cytometry. Part B, 2019, v. 96, n. 6, p. 475, doi. 10.1002/cyto.b.21736

By:

Wu, Fan;
Pan, Ying;
Wang, Huiping;
Tao, Qianshan;
An, Furun;
Zhang, Jiakui;
Zhai, Zhimin

Publication type:

Article

Therapeutic potential of low‐dose IL‐2 in immune thrombocytopenia: An analysis of 3 cases.

Published in:

Cytometry. Part B, 2018, v. 94, n. 3, p. 428, doi. 10.1002/cyto.b.21601

By:

Zhang, Jiakui;
Ruan, Yanjie;
Xu, Xuanxuan;
Wang, Huiping;
Tao, Qianshan;
Lu, Jun;
Xia, Linhuan;
Zhang, Qiuye;
Wang, Jeffrey;
Wang, Yiping;
Zhai, Zhimin

Publication type:

Article

Low dose IL‐2 increase regulatory T cells and elevate platelets in a patient with immune thrombocytopenia.

Published in:

Cytometry. Part B, 2018, v. 94, n. 3, p. 400, doi. 10.1002/cyto.b.21494

By:

Zhang, Jiakui;
Ruan, Yanjie;
Shen, Yuanyuan;
Tao, Qianshan;
Wang, Huiping;
Tao, Lili;
Pan, Yin;
Fang, Huizi;
Wang, Yiping;
Zhai, Zhimin

Publication type:

Article

Flow cytometry used to identify histiocytic sarcoma: A case report.

Published in:

Cytometry. Part B, 2016, v. 90, n. 6, p. 546, doi. 10.1002/cyto.b.21262

By:

Wang, Huiping;
Zhang, Jiakui;
Tao, Qianshan;
Bian, Hengjuan;
Shen, Yuanyuan;
Li, Yingwei;
Tao, Lili;
Wang, Chunhuai;
Wang, Yiping;
Zhai, Zhimin

Publication type:

Article

Lenalidomide Treatment of Isolated Central Nervous System Relapse in Acute Lymphoblastic Leukemia after Hematopoietic Stem Cell Transplantation and Chimeric Antigen Receptor T-Cell Therapy.

Published in:

Acta Haematologica, 2024, v. 147, n. 5, p. 592, doi. 10.1159/000537719

By:

Zhang, Qing;
Dong, Yi;
Zhai, Zhimin;
Tao, Lili;
Tao, Qianshan

Publication type:

Article

Changes of peripheral blood immune cells in acute coronary syndrome.

Published in:

2019

By:

Zhang, Chengxin;
Liu, Haiyuan;
Wang, Huiping;
Tao, Qianshan;
Lin, Xianhe;
Ge, Shenglin;
Zhai, Zhimin

Publication type:

Letter

Changes of peripheral blood immune cells in acute coronary syndrome.

Published in:

2019

By:

Zhang, Chengxin;
Liu, Haiyuan;
Wang, Huiping;
Tao, Qianshan;
Lin, Xianhe;
Ge, Shenglin;
Zhai, Zhimin

Publication type:

Letter

Effect of herpes zoster vaccine on patients after hematopoietic stem cell transplantation: a systematic review and meta-analysis.

Published in:

2025

By:

Jiao, Xunyi;
Zhu, Jinli;
Ding, Yangyang;
Xiao, Meng;
Zhai, Zhimin

Publication type:

Literature Review

Gp350-targeted CAR-T therapy in EBV-positive Burkitt lymphoma: pre-clinical development of gp350 CAR-T.

Published in:

Journal of Translational Medicine, 2025, v. 23, n. 1, p. 1, doi. 10.1186/s12967-025-06188-w

By:

Wang, Jiajia;
Wang, Huiping;
Ding, Yangyang;
Cao, Nengneng;
Nan, Fengya;
Wu, Fan;
Li, Cong;
Liang, Xue;
Xiao, Meng;
Guo, Jinjing;
Gao, Zhimai;
Yan, Li;
Zhou, Tielin;
Li, Yanli;
Zhai, Zhimin

Publication type:

Article

The interaction of innate immune and adaptive immune system.

Published in:

MedComm, 2024, v. 5, n. 10, p. 1, doi. 10.1002/mco2.714

By:

Wang, Ruyuan;
Lan, Caini;
Benlagha, Kamel;
Camara, Niels Olsen Saraiva;
Miller, Heather;
Kubo, Masato;
Heegaard, Steffen;
Lee, Pamela;
Yang, Lu;
Forsman, Huamei;
Li, Xingrui;
Zhai, Zhimin;
Liu, Chaohong

Publication type:

Article

Targeting regulatory T cells in cytokine-induced killer cell cultures (Review).

Published in:

Biomedical Reports, 2014, v. 2, n. 3, p. 317, doi. 10.3892/br.2014.234

By:

QIANSHAN TAO;
HUIPING WANG;
ZHIMIN ZHAI

Publication type:

Article

Decitabine in patients with myelodysplastic syndromes: A multi‐center, open‐label, dose comparison trial.

Published in:

Cancer Medicine, 2023, v. 12, n. 13, p. 13885, doi. 10.1002/cam4.5922

By:

Liu, Hui;
Jiang, Hao;
Tong, Hongyan;
Xia, Ruixiang;
Yang, Linhua;
Zhao, Hongguo;
Ouyang, Jian;
Bai, Hai;
Sun, Hui;
Hou, Li;
Jiang, Ming;
Zeng, Yun;
Liu, Zhuogang;
Liang, Aibin;
Xie, Yinghua;
Yu, Kang;
Zhai, Zhimin;
Liu, Li;
Jia, Jinsong;
Fu, Rong

Publication type:

Article

Super-Enhancer-Associated nine-gene prognostic score model for prediction of survival in chronic lymphocytic leukemia patients.

Published in:

Frontiers in Genetics, 2022, v. 13, p. 1, doi. 10.3389/fgene.2022.1001364

By:

Xue Liang;
Ye Meng;
Cong Li;
Linlin Liu;
Yangyang Wang;
Lianfang Pu;
Linhui Hu;
Qian Li;
Zhimin Zhai

Publication type:

Article

Influence of patient characteristics on chimeric antigen receptor T cell therapy in B-cell acute lymphoblastic leukemia.

Published in:

Nature Communications, 2020, v. 11, n. 1, p. N.PAG, doi. 10.1038/s41467-020-19774-x

By:

An, Furun;
Wang, Huiping;
Liu, Zhenyun;
Wu, Fan;
Zhang, Jiakui;
Tao, Qianshan;
Li, Yingwei;
Shen, Yuanyuan;
Ruan, Yanjie;
Zhang, Qing;
Pan, Ying;
Zhu, Weiwei;
Qin, Hui;
Wang, Yansheng;
Fu, Yongling;
Feng, Zhenqing;
Zhai, Zhimin

Publication type:

Article

Simultaneous Presentation of Disseminated Intravascular Coagulation and Hemophagocytic Syndrom in a Patient with Adult-Onset Still's Disease.

Published in:

Journal of the College of Physicians & Surgeons Pakistan, 2014, v. 24, n. 5, p. 379

By:

Kaili Yan;
Tianping Chen;
Huiping Wang;
Qianshan Tao;
Yinwei Li;
Chunhuai Wang;
Shudao Xiong;
Zhimin Zhai

Publication type:

Article

Integrative analysis of hub genes and key pathway in two subtypes of diffuse large B‐cell lymphoma by bioinformatics and basic experiments.

Published in:

Journal of Clinical Laboratory Analysis, 2021, v. 35, n. 11, p. 1, doi. 10.1002/jcla.23978

By:

Li, Qian;
Meng, Ye;
Hu, Linhui;
Charwudzi, Alice;
Zhu, Weiwei;
Zhai, Zhimin

Publication type:

Article

Tumor necrosis factor alpha-stimulated gene-6 (TSG-6) inhibits the inflammatory response by inhibiting the activation of P38 and JNK signaling pathway and decreases the restenosis of vein grafts in rats.

Published in:

Heart & Vessels, 2017, v. 32, n. 12, p. 1536, doi. 10.1007/s00380-017-1059-3

By:

Zhang, Chengxin;
Zhang, Biao;
Wang, Huiping;
Tao, Qianshan;
Ge, Shenglin;
Zhai, Zhimin

Publication type:

Article

Correlation of the CD4+CD25high T-regulatory cells in recipients and their corresponding donors to acute GVHD.

Published in:

Transplant International, 2007, v. 20, n. 5, p. 440, doi. 10.1111/j.1432-2277.2007.00462.x

By:

Zhai, Zhimin;
Sun, Zimin;
Li, Qing;
Zhang, Aimei;
Liu, Huilan;
Xu, Jingwei;
Xu, Xiucai;
Geng, Liangquan;
Harris, David;
Hu, Shilian;
Wang, Yiping

Publication type:

Article

Level and clinical significance of CD4+CD25+CD127low regulatory T cell in patients with diffuse large B-cell lymphoma.

Published in:

Chinese Journal of Immunology, 2025, v. 41, n. 5, p. 1102, doi. 10.3969/j.issn.1000-484X.2025.05.014

By:

HUANG Keke;
WANG Jiyu;
WANG Huiping;
ZHAI Zhimin

Publication type:

Article

Changes and clinical significance of senescent cell proportion and senescence-associated cytokines in acute myeloid leukemia.

Published in:

Chinese Journal of Immunology, 2024, v. 40, n. 10, p. 2141, doi. 10.3969/j.issn.1000-484X.2024.10.020

By:

LIU Linlin;
TAO Qianshan;
WANG Huiping;
ZHANG Qing;
ZHAI Zhimin

Publication type:

Article

Elevated M-MDSCs in Circulation Are Indicative of Poor Prognosis in Diffuse Large B-Cell Lymphoma Patients.

Published in:

Journal of Clinical Medicine, 2021, v. 10, n. 8, p. 1768, doi. 10.3390/jcm10081768

By:

Wang, Zhitao;
Jiang, Rui;
Li, Qian;
Wang, Huiping;
Tao, Qianshan;
Zhai, Zhimin

Publication type:

Article

Long non-coding RNA HOTAIR regulates myeloid differentiation through the upregulation of p21 via miR-17-5p in acute myeloid leukaemia.

Published in:

RNA Biology, 2021, v. 18, n. 10, p. 1434, doi. 10.1080/15476286.2020.1854520

By:

Hu, Linhui;
Liu, Jun;
Meng, Ye;
Zheng, Huimin;
Ding, Chen;
Wang, Huiping;
Charwudzi, Alice;
Li, Manman;
Li, Jingrong;
Zhai, Zhimin;
Xiong, Shudao

Publication type:

Article

Lipid levels and multiple myeloma risk: insights from Meta-analysis and mendelian randomization.

Published in:

Lipids in Health & Disease, 2024, v. 23, n. 1, p. 1, doi. 10.1186/s12944-024-02289-5

By:

Zhu, Weiwei;
Charwudzi, Alice;
li, Qian;
Zhai, Zhimin;
Hu, Linhui;
Pu, Lianfang

Publication type:

Article

Quartic CAR-T Cell Bridging to Twice Allo-HSCT Therapy in a Patient with Acute Lymphoblastic Leukemia.

Published in:

Transfusion Medicine & Hemotherapy, 2024, v. 51, n. 1, p. 55, doi. 10.1159/000531681

By:

Zhang, Qing;
Dong, Yi;
Zhai, Zhimin;
Tao, Qianshan

Publication type:

Article

All-trans-Retinoic Acid Ameliorated High Fat Diet-Induced Atherosclerosis in Rabbits by Inhibiting Platelet Activation and Inflammation.

Published in:

2012

By:

Birong Zhou;
Ying Pan;
Zeping Hu;
Xiaobian Wang;
Jianxiong Han;
Qing Zhou;
Zhimin Zhai;
Yuan Wang

Publication type:

Journal Article