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- Title
Comparative LC-MS/MS and HPLC-UV Analyses of Meropenem and Piperacillin in Critically Ill Patients.
- Authors
Paal, Michael; Heilmann, Marcus; Koch, Simone; Bertsch, Thomas; Steinmann, Jörg; Höhl, Rainer; Liebchen, Uwe; Schuster, Carina; Kleine, Frederick M; Vogeser, Michael
- Abstract
Therapeutic drug monitoring (TDM) of beta-lactam antibiotics has become a valuable tool to guide dosing in critically ill patients. The main goal of the study was to compare two routinely used techniques for beta-lactam TDM in intensive care unit (ICU) patient samples, namely isotope dilution liquid chromatography tandem mass spectrometry (ID-LC-MS/MS) and high-performance liquid chromatography combined with ultra-violet detection (HPLC-UV).
- Publication
Clinical laboratory, 2019, Vol 65, Issue 9
- ISSN
1433-6510
- Publication type
Journal Article
- DOI
10.7754/Clin.Lab.2019.190210