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- Title
[Expression of MCL-1 and microRNA-29a in extranodal NK/T-cell lymphoma tissue].
- Authors
Huang, Hao-Bo; Zhan, Rong; Wu, Shun-Quan; Xu, Zhen-Zhen; Fan, Li-Ping
- Abstract
This study was aimed to explore the expression level and correlation of MCL-1 and miR-29a in extranodal NK/T-cell lymphoma (ENKTCL) tissue. Maxvision immunohistochemistry technique and real time fluorescent quantitative PCR were used to detect the expression level of MCL-1 and miR-29a in tissue of 20 patients with ENKTCL and 10 patients with proliferative lymphadenitis, respectively. The results showed that the expression of MCL-1 protein were higher in patients with ENKTCL than that in patients with proliferative lymphadenitis, but there were no significant correlation between MCL-1 overexpression and age, sex, Ann Arbor stage and International Prognostic Index (IPI), respectively. Correlation analysis indicated that there was significant negative correlation between miR-29a expression and MCL-1 expression (r = -0.59, P = 0.016). It is concluded that miR-29a may target MCL-1 gene, regulate its expression, then participate in tumorigenesis and development of ENKTCL.
- Publication
Zhongguo shi yan xue ye xue za zhi, 2013, Vol 21, Issue 1, p95
- ISSN
1009-2137
- Publication type
Journal Article
- DOI
10.7534/j.issn.1009-2137.2013.01.020