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- Title
Scleroderma, Sjögren-like syndrome, and chronic graft-versus-host disease.
- Authors
Lawley, T J; Peck, G L; Moutsopoulos, H M; Gratwohl, A A; Deisseroth, A B
- Abstract
A patient with acute myelogenous leukemia treated with an allogeneic bone marrow transplant developed acute graft-versus-host disease manifested by severe diarrhea, hepatitis, and a cutaneous eruption. As the graft-versus-host disease progressed to the chronic phase, the patient developed marked cutaneous sclerosis and symptoms of xerophthalmia and xerostomia. Biopsy of his indurated skin showed features of both graft-versus-host disease and scleroderma. Results of Schirmer's tests, corneal fluorescent studies, parotid flow-rate testing, and a lip biopsy were consistent with Sjögren's syndrome. Possibly, activated lymphocytes may have a role in the pathogenesis of graft-versus-host disease, scleroderma, and Sjögren's syndrome.
- Publication
Annals of internal medicine, 1977, Vol 87, Issue 6, p707
- ISSN
0003-4819
- Publication type
Journal Article
- DOI
10.7326/0003-4819-87-6-707