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- Title
Safety and effectiveness of long-acting inhaled beta-agonist bronchodilators when taken with inhaled corticosteroids.
- Authors
Ernst, Pierre; McIvor, Andrew; Ducharme, Francine M; Boulet, Louis-Philippe; FitzGerald, Mark; Chapman, Kenneth R; Bai, Tony; Canadian Asthma Guideline Group
- Abstract
Long-acting beta-agonists are a pillar of therapy for many patients with asthma because they are the preferred add-on therapy to inhaled corticosteroids. However, a recent meta-analysis documented a substantial increase in severe exacerbations requiring hospital admission and life-threatening asthma exacerbations in patients treated with long-acting beta-agonists. A careful evaluation of this meta-analysis raises several concerns about its applicability to current practice. Pivotal trials evaluating the benefit of adding long-acting beta-agonists to inhaled corticosteroids were not included. The authors of the current paper call for physicians to continue their usual practice of using long-acting beta-agonists as adjunctive therapy, as well as for an independent meta-analysis of individual patients using inhaled corticosteroids and long-acting beta-agonists concomitantly.
- Publication
Annals of internal medicine, 2006, Vol 145, Issue 9, p692
- ISSN
1539-3704
- Publication type
Journal Article
- DOI
10.7326/0003-4819-145-9-200611070-00012