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- Title
Clinical Trial Registration: A Statement from the International Committee of Medical Journal Editors.
- Abstract
This article presents a suggestive note on standards and procedures of clinical trial registration, based on a statement from the International Committee of Medical Journal Editors (ICMJE). The case against selective reporting is particularly compelling for research that tests interventions that could enter mainstream clinical practice. Rather than a single trial, it is usually a body of evidence, consisting of many studies, that changes medical practice. When research sponsors or investigators conceal the presence of selected trials, these studies cannot influence the thinking of patients, clinicians, other researchers, and experts who write practice guidelines or decide on insurance-coverage policy. If all trials are registered in a public repository at their inception, every trial's existence is part of the public record and the many stakeholders in clinical research can explore the full range of clinical evidence. In this regard, ICMJE proposes comprehensive trials registration as a solution to the problem of selective awareness and announces that all 11 ICMJE member journals will adopt a trials- registration policy to promote this goal.
- Publication
Annals of Internal Medicine, 2004, Vol 141, Issue 6, p477
- ISSN
0003-4819
- Publication type
Academic Journal
- DOI
10.7326/0003-4819-141-6-200409210-00109