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- Title
Association of Hemoglobin A<sub>1c</sub> with Cardiovascular Disease and Mortality in Adults: The European Prospective Investigation into Cancer in Norfolk.
- Authors
Khaw, Kay-tee; Wareham, Nicholas; Bingham, Sheila; Luben, Robert; Welch, Ailsa; Day, Nicholas
- Abstract
This article deals with a study examining the relationship between hemoglobin A1c, cardiovascular disease, and total mortality. This study was performed on 4662 men and 5570 women who were 45 to 79 years of age and were residents of Norfolk, England. Hemoglobin A1c and cardiovascular disease risk factors were assessed from 1995 to 1997, and cardiovascular disease events and mortality were assessed during the follow-up period to 2003. It was found that in men and women, the relationship between hemoglobin A 1c and cardiovascular disease and between hemoglobin A1c and all-cause mortality was continuous and significant throughout the whole distribution. The relationship was apparent in persons without known diabetes. These findings support the need for randomized trials of interventions to reduce hemoglobin A1c concentrations in persons without diabetes.
- Publication
Annals of Internal Medicine, 2004, Vol 141, Issue 6, p413
- ISSN
0003-4819
- Publication type
Academic Journal
- DOI
10.7326/0003-4819-141-6-200409210-00006