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- Title
Alcohol Intake and Colorectal Cancer: A Pooled Analysis of 8 Cohort Studies.
- Authors
Eunyoung Cho; Smith-Warner, Stephanie A.; Ritz, John; van den Brandt, Piet A.; Colditz, Graham A.; Folsom, Aaron R.; Freudenheim, Jo L.; Giovannucci, Edward; Goldbohm, R. Alexandra; Graham, Saxon; Holmberg, Lars; Kim, Dong-Hyun; Malila, Nea; Miller, Anthony B.; Pietinen, Pirjo; Rohan, Thomas E.; Sellers, Thomas A.; Speizer, Frank E.; Willett, Walter C.; Wolk, Alicja
- Abstract
Background: Epidemiologic studies have generally reported positive associations between alcohol consumption and risk for colorectal cancer. However, findings related to specific alcoholic beverages or different anatomic sites in the large bowel have been inconsistent. Objective: To examine the relationship of total alcohol intake and intake from specific beverages to the incidence of colorectal cancer and to evaluate whether other potential risk factors modify the association. Design: Pooled analysis of primary data from 8 cohort studies in 5 countries. Setting: North America and Europe. Participants: 489 979 women and men with no history of can-cer other than nonmelanoma skin cancer at baseline. Measurements: Alcohol intake was assessed in each study at baseline by using a validated food-frequency questionnaire. Results: During a maximum of 6 to 16 years of follow-up across the studies, 4687 cases of colorectal cancer were documented. In categorical analyses, increased risk for colorectal cancer was...
- Publication
Annals of Internal Medicine, 2004, Vol 140, Issue 8, p603
- ISSN
0003-4819
- Publication type
Academic Journal
- DOI
10.7326/0003-4819-140-8-200404200-00007