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- Title
Placebo-controlled trials and active-control trials in the evaluation of new treatments. Part 2: practical issues and specific cases.
- Authors
Ellenberg, S S; Temple, R
- Abstract
Placebo controls are commonly used in clinical trials of investigational treatments because they have important advantages. In recent years, some have criticized the use of placebo-controlled trials when effective alternative therapy exists, regardless of the expected effect of the therapy. In part 1 of this paper, ethical arguments are addressed and the interpretive problems inherent in the use of active-control equivalence trials to establish efficacy of a new treatment are clarified. However, uncertainties may complicate decisions about appropriate use of placebo controls in some situations. Part 2 discusses more fully the ethical considerations for using placebo controls in particular medical settings. The value and relevance of placebo-controlled trials of new agents in situations in which proven effective therapy is available are also explored.
- Publication
Annals of internal medicine, 2000, Vol 133, Issue 6, p464
- ISSN
0003-4819
- Publication type
Journal Article
- DOI
10.7326/0003-4819-133-6-200009190-00015