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- Title
Polymerase chain reaction for the diagnosis of HIV infection in adults. A meta-analysis with recommendations for clinical practice and study design.
- Authors
Owens, D K; Holodniy, M; Garber, A M; Scott, J; Sonnad, S; Moses, L; Kinosian, B; Schwartz, J S
- Abstract
To do a meta-analysis of studies that have evaluated the sensitivity and specificity of polymerase chain reaction (PCR) assay for the diagnosis of human immunodeficiency virus (HIV) infection in adults. Evaluating the performance of PCR is difficult because in certain clinical situations, the sensitivity or specificity of PCR may exceed those of the current reference standard tests (enzyme immunoassay followed by confirmatory Western blot analysis). Therefore, an additional goal was to develop recommendations for 1) the design of future evaluative studies of PCR and 2) the use of PCR in persons with suspected HIV infection.
- Publication
Annals of internal medicine, 1996, Vol 124, Issue 9, p803
- ISSN
0003-4819
- Publication type
Journal Article
- DOI
10.7326/0003-4819-124-9-199605010-00004