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- Title
Genetic relatedness of lymphoid malignancies. Transformation of chronic lymphocytic leukemia as a model.
- Authors
Foon, K A; Thiruvengadam, R; Saven, A; Bernstein, Z P; Gale, R P
- Abstract
Studies concerning the genetic relatedness between chronic lymphocytic leukemia and the more aggressive B-cell cancers that develop in about 10% of affected persons were reviewed. These B-cell cancers include large B-cell lymphoma (the Richter syndrome), prolymphocytic transformation, acute lymphoblastic leukemia, and multiple myeloma. Two possible relations were evaluated: development from the chronic lymphocytic leukemia clone (clonal evolution) and development of a genetically unrelated, independent second cancer.
- Publication
Annals of internal medicine, 1993, Vol 119, Issue 1, p63
- ISSN
0003-4819
- Publication type
Journal Article
- DOI
10.7326/0003-4819-119-1-199307010-00011