Works matching DE "DRUG development"

Results: 5000

A Systematic Assessment of Drug Repurposing Efforts Against COVID‐19: Limited Successes and Key Challenges.

Published in:

Journal of Clinical Pharmacy & Therapeutics, 2025, v. 2025, p. 1, doi. 10.1155/jcpt/3796111

By:

Riedel, Andreas;
Ruth, Peter;
Löffler, Markus W.;
Stransky, Nicolai;
Iqhrammullah, Muhammad

Publication type:

Article

Catch me if you can: viral nucleic acids to host sensors.

Published in:

Frontiers in Immunology, 2025, p. 1, doi. 10.3389/fimmu.2025.1632283

By:

Jung, Yohan;
Grainger, Harmony;
Yang, Shizhuo;
Mondal, Sohaumn;
Lukong, Kiven Erique;
Conn, Kristen;
Wu, Yuliang

Publication type:

Article

The Applications and Outlook of Organ-on-a-Chip in Pharmacy and Pharmacology (Review).

Published in:

Pharmaceutical Chemistry Journal, 2025, v. 59, n. 4, p. 485, doi. 10.1007/s11094-025-03419-8

By:

Xu, Xin-Yu;
Zhao, Zi-Xin;
Liang, Zhao-Long;
Zhao, Xin-Ru;
Yao, Chun-Lei;
Xuan, Yang

Publication type:

Article

Antimicrobial Screening and Molecular Docking Simulation of 2-Aminopyrimidin-1-Ium 4-Nitrobenzenesulfonate as a New Proton Transfer Compound.

Published in:

Pharmaceutical Chemistry Journal, 2025, v. 59, n. 4, p. 445, doi. 10.1007/s11094-025-03413-0

By:

Atefi, Aref;
Larypoor, Mohaddeseh;
Tabatabaee, Masoumeh;
Bahramali, Golnaz

Publication type:

Article

Digital Pathology and Artificial Intelligence Applied to Nonclinical Toxicology Pathology—The Current State, Challenges, and Future Directions.

Published in:

Toxicologic Pathology, 2025, v. 53, n. 6, p. 516, doi. 10.1177/01926233251340622

By:

Pohlmeyer-Esch, Gabriele;
Halsey, Charles;
Boisclair, Julie;
Ram, Sripad;
Kirschner-Kitz, Sarah;
Knight, Brian;
Moulin, Pierre;
Frisk, Anna-Lena

Publication type:

Article

原发性胆汁性胆管炎个性化诊疗策略.

Published in:

Journal of Clinical Hepatology / Linchuang Gandanbing Zazhi, 2025, v. 41, n. 7, p. 1270, doi. 10.12449/JCH250707

By:

郑, 林华;
韩, 英

Publication type:

Article

FLOR DE PIEDRA.

Published in:

Etnobiología, 2025, p. 65

By:

Landeros, Fidel;
Ulises Esquivel-Naranjo, Edgardo;
Karenia Caltzontzin-Fernández, Kruskaia;
Manuel Ferrusca-Rico, Felipe

Publication type:

Article

Catch me if you can: viral nucleic acids to host sensors.

Published in:

Frontiers in Immunology, 2025, p. 1, doi. 10.3389/fimmu.2025.1632283

By:

Jung, Yohan;
Grainger, Harmony;
Yang, Shizhuo;
Mondal, Sohaumn;
Lukong, Kiven Erique;
Conn, Kristen;
Wu, Yuliang

Publication type:

Article

Integrating mHealth Innovations into Decentralized Oncology Trials.

Published in:

Journal of Medical Systems, 2025, v. 49, n. 1, p. 1, doi. 10.1007/s10916-025-02233-9

By:

Cicin, Fatma Nur;
Cicin, Irfan

Publication type:

Article

FDA Grants Accelerated Approval to Zongertinib for Nonsquamous NSCLC With HER2 TKD–Activating Variants.

Published in:: ONS Voice, 2025, p. N.PAG
Publication type:: Article

Bridging the gaps in detection of structural cardiotoxicity in stem cell-derived cardiomyocytes: promise of miR-133b, miR-184 and miR-208b-3p.

Published in:

Frontiers in Pharmacology, 2025, p. 1, doi. 10.3389/fphar.2025.1584734

By:

Cherubin, M.;
Delaunois, A.;
Valentin, J. P.;
Alaerts, M.;
Guns, P. J.;
Gryshkova, V.

Publication type:

Article

Secondary Metabolites of Trichoderma spirale.

Published in:

Chemistry of Natural Compounds, 2025, v. 61, n. 4, p. 821, doi. 10.1007/s10600-025-04771-7

By:

Zhi, Jia-le;
Zhang, Xia;
Wang, Xin-yang;
Zhang, Juan-juan;
Guo, Qing-feng;
Yin, Zhen-hua;
Yang, Bao-cheng;
Chen, Lin

Publication type:

Article

REVOLUTIONIZING TUBERCULOSIS REGIMEN DEVELOPMENT.

Published in:

Transactions of the American Clinical & Climatological Association, 2025, n. 135, p. 269

By:

DOOLEY, KELLY E.

Publication type:

Article

NMDA receptors in neurodegenerative diseases: mechanisms and emerging therapeutic strategies.

Published in:

Frontiers in Aging Neuroscience, 2025, p. 1, doi. 10.3389/fnagi.2025.1604378

By:

Zhang, Keyi;
Wen, Ming;
Nan, Xinyue;
Zhao, Shuaizhu;
Li, Hao;
Ai, Yanping;
Zhu, Houze

Publication type:

Article

An Artificial Intelligence Pipeline for Hepatocellular Carcinoma: From Data to Treatment Recommendations.

Published in:

International Journal of General Medicine, 2025, v. 18, p. 3581, doi. 10.2147/IJGM.S529322

By:

Zhang, Xuebing;
Yang, Liuxin;
Liu, Chengxiang;
Yuan, Xingxing;
Zhang, Yali

Publication type:

Article

A Comprehensive Review on the Role of Natural Plants in Anti-Bacterial Activity.

Published in:

Journal of Drug Delivery & Therapeutics, 2025, v. 15, n. 7, p. 116, doi. 10.22270/jddt.v15i7.7200

By:

Tatiya, Anilkumar. U.;
Anil, Pagar Pranali

Publication type:

Article

Interagency Collaboration for Patient-Centered Antibacterial Drug Development.

Published in:

Clinical Infectious Diseases, 2025, v. 81, p. S11, doi. 10.1093/cid/ciaf298

By:

Howard-Anderson, Jessica;
Doernberg, Sarah B;
Dixon, Dennis;
Gopinath, Ramya;
Rubin, Daniel;
Kinamon, Tori;
Kim, Peter;
Collyar, Deborah;
Cosgrove, Sara E;
Fowler, Vance G;
Chambers, Henry F;
Evans, Scott R;
Holland, Thomas L;
King, Heather A;
Boucher, Helen W

Publication type:

Article

Patient-Reported Outcomes and Health-Related Quality-of-Life Measures in Infectious Diseases Studies and Clinical Practice.

Published in:

Clinical Infectious Diseases, 2025, v. 81, p. S1, doi. 10.1093/cid/ciaf297

By:

Powers, John H;
Nambiar, Sumati

Publication type:

Article

Machine learning analysis of ARVC informed by sodium channel protein-based interactome networks.

Published in:

Frontiers in Pharmacology, 2025, p. 1, doi. 10.3389/fphar.2025.1611342

By:

Zhu, Yanan;
Zhang, Hui;
Zhao, Xuan;
Wang, Xin;
Xing, Lina;
Yao, Sijie;
Jin, Xiao;
Li, Tingting;
Dai, Ting;
Ding, Xinyue;
Qi, Zhen;
Liu, Zongjun

Publication type:

Article

Cross-cultural treatment preferences: a call for diversity in drug development.

Published in:

Current Medical Research & Opinion, 2025, v. 41, n. 6, p. 1047, doi. 10.1080/03007995.2025.2537298

By:

Dijkgraaf, Dana M.;
Kiani, Pantea;
Zijlstra, Maureen N.;
Verster, Joris C.

Publication type:

Article

Exploring Aspergillus ochraceopetaliformis: Biosynthesis, chemical diversity, and pharmacological potential of its secondary metabolites.

Published in:

Journal of Applied Pharmaceutical Science, 2025, v. 15, n. 7, p. 67, doi. 10.7324/JAPS.2025.232603

By:

Mohamed, Hagar M.;
Mohamed, Shaimaa G. A.;
Ashour, Ahmed;
Hussein, Hazem G. A.;
Osman, Wadah;
Mohamed, Gamal A.;
Ibrahim, Sabrin R. M.

Publication type:

Article

Design, synthesis, and biological evaluation of potent anti-fatigue compounds based on 1-BCP targeting the AMPA receptor.

Published in:

Arabian Journal of Chemistry, 2025, v. 18, n. 5, p. 1, doi. 10.25259/AJC_89_2025

By:

Yang, Xin;
Cui, Yaowen;
He, Zhaolun;
Xu, Jing;
Chen, Tingting;
Liu, Shuchen;
Wang, Lin;
Zhang, Shouguo

Publication type:

Article

Sustainable synthesis of bivalent Ni2+, Co2+, and Cu2+ Schiff base complexes via ball milling as a green approach: A study of spectroscopic characterization, cyclic voltammetry, bioactivity, DFT analysis, SAR, drug likeness, and molecular docking

Published in:

Arabian Journal of Chemistry, 2025, v. 18, n. 4, p. 1, doi. 10.25259/AJC_56_2025

By:

Abou-Melha, Khlood Saad A.

Publication type:

Article

Incremental therapeutic value of FDA-designated "breakthrough" drugs based on ratings from four international organizations: a cross-sectional study Open Access.

Published in:

Journal of Pharmaceutical Health Services Research, 2025, v. 16, n. 2, p. 1, doi. 10.1093/jphsr/rmaf009

By:

Borisova, Elizaveta;
Darrow, Jonathan;
Lexchin, Joel

Publication type:

Article

Moving the needle on immune checkpoint inhibitors with novel targets: are we being TIMid or LAGging behind?

Published in:

Oncologist, 2025, v. 30, n. 7, p. 1, doi. 10.1093/oncolo/oyaf145

By:

Park, Changsu Lawrence;
Bedard, Philippe L

Publication type:

Article

3D conformation and crystal interaction insights into drug development challenges for HCV drug analogues via molecular simulations.

Published in:

Communications Chemistry, 2025, v. 8, n. 1, p. 1, doi. 10.1038/s42004-025-01618-8

By:

Hong, Richard S.;
Mattei, Alessandra;
Tuckerman, Mark E.;
Sheikh, Ahmad Y.

Publication type:

Article

A Conversation With Amy Racine‐Poon.

Published in:

International Statistical Review, 2025, v. 93, n. 2, p. 183, doi. 10.1111/insr.12605

By:

Sverdlov, Oleksandr

Publication type:

Article

Strychnos peckii B.L. Rob.: secondary metabolite annotation by liquid chromatography tandem high-resolution mass spectrometry with insights from biogenesis.

Published in:

Analytical & Bioanalytical Chemistry, 2025, v. 417, n. 20, p. 4557, doi. 10.1007/s00216-025-05967-0

By:

Cassas, Fernando;
Santos, Carla L. G.;
da Silva, Felipe M. A.;
Cass, Quezia B.

Publication type:

Article

The Hsp90β Isoform: An Attractive Target for Drug Development.

Published in:

Medicinal Research Reviews, 2025, v. 45, n. 5, p. 1452, doi. 10.1002/med.22114

By:

Chaudhury, Subhabrata;
D'Amico, Terin;
Blagg, Brian S. J.

Publication type:

Article

大蒜活性成分抗肿瘤作用及其机制研究进展.

Published in:

Journal of Food Safety & Quality, 2025, v. 16, n. 16, p. 166, doi. 10.19812/j.cnki.jfsq11-5956/ts.20250327001

By:

胡艳茹;
邓晓东;
赵志伟;
刘祎雯;
杨雯静;
盛宇涵;
李伟;
舒馨;
张薇薇

Publication type:

Article

Recaticimab: First Approval.

Published in:

Drugs, 2025, v. 85, n. 8, p. 1067, doi. 10.1007/s40265-025-02199-5

By:

Lamb, Yvette N.

Publication type:

Article

Sipavibart: First Approval.

Published in:

Drugs, 2025, v. 85, n. 8, p. 1049, doi. 10.1007/s40265-025-02186-w

By:

Keam, Susan J.

Publication type:

Article

Limertinib: First Approval.

Published in:

Drugs, 2025, v. 85, n. 8, p. 1055, doi. 10.1007/s40265-025-02184-y

By:

Lee, Arnold

Publication type:

Article

Accelerating the Understanding of Biosensors Through the Lens of Cells: State of the Field, Emerging Directions, Advances, and Challenges.

Published in:

Applied Biochemistry & Biotechnology, 2025, v. 197, n. 7, p. 4224, doi. 10.1007/s12010-025-05209-0

By:

Narang, Jasjeet;
Rana, Niket;
Chauhan, Arjun;
Kumari, Anushka;
Minhas, Vanshika

Publication type:

Article

Efficient and Rapid Arylation of NH₂‐Unprotected Bromobisindole Ethanamines via Suzuki‐Miyaura Coupling: Generating New Leads Against Leishmania.

Published in:

Chemistry - A European Journal, 2025, v. 31, n. 43, p. 1, doi. 10.1002/chem.202500637

By:

Buono, Alessandro;
Diotallevi, Aurora;
Maestrini, Sara;
Verboni, Michele;
Kiuru, Paula;
Galluzzi, Luca;
Duranti, Andrea;
Olivieri, Diego;
Lucarini, Simone

Publication type:

Article

Advances and challenges of targeting epicardial adipose tissue (EAT) and perivascular adipose tissue (PVAT).

Published in:

Cardiovascular Diabetology, 2025, v. 24, n. 1, p. 1, doi. 10.1186/s12933-025-02763-z

By:

Liu, Dan;
Chen, Wujun;
Guo, Zhu;
Gao, Qun;
Wang, Bin;
Wang, Jie;
Hu, Weichao;
Wang, Chao;
Wang, Shuai;
Wu, Xiaolin;
Xu, Mantao;
Lan, Ganqiu

Publication type:

Article

Genomic characterization and pre-clinical evaluation of a new polyvalent lytic Loughborough phage.

Published in:

Applied Microbiology & Biotechnology, 2025, v. 109, n. 1, p. 1, doi. 10.1007/s00253-025-13559-2

By:

Sherif, Mahmoud M.;
Abdelaziz, Neveen A.;
Saleh, Sarra E.;
Aboshanab, Khaled M.

Publication type:

Article

In silico target identification and pharmacokinetic profiling of 2-aryl-quinoline-4-carboxylic acid derivatives as potential antileishmanial agents.

Published in:

Frontiers in Pharmacology, 2025, p. 1, doi. 10.3389/fphar.2025.1621059

By:

da Silva, Marília Cecília;
Viana, Jéssika de Oliveira;
Olegário, Tayná Rodrigues;
Sabino, Jayne Maria;
Barbosa, Euzébio Guimarães;
Chaves, Elton José Ferreira;
Rocha, Gerd Bruno;
Lima-Junior, Claudio Gabriel;
Weber, Karen Cacilda

Publication type:

Article

Preclinical evaluation of dose-dependent effects of photobiomodulation therapy on persistent inflammation in the temporomandibular joint.

Published in:

Journal of Oral & Facial Pain & Headache, 2025, v. 39, n. 2, p. 183, doi. 10.22514/jofph.2025.037

By:

Almeida Carvalho, Vinicius;
Almeida Martins, Amanda;
de Carvalho Desiderá, Amanda;
Crivelaro Nascimento, Glauce;
Valencise Magri, Laís;
Andrade Leite-Panissi, Christie Ramos

Publication type:

Article

Analysis of advanced technologies for 3D printing of pharmaceutical products for personalised medicine: A review.

Published in:

Archives of Materials Science & Engineering, 2025, v. 132, n. 1, p. 29, doi. 10.5604/01.3001.0055.2154

By:

Panova, N. K.;
Nikolova, K. T.;
Dikova, T. D.

Publication type:

Article

Dose-response characterization: A key to success in drug development.

Published in:

Clinical Trials, 2025, v. 22, n. 4, p. 384, doi. 10.1177/17407745251350289

By:

Bretz, Frank;
Bornkamp, Björn;
Dumortier, Thomas

Publication type:

Article

Comparison of adaptive seamless Phase 2/3 designs for dose selection in clinical trials with multiple endpoints.

Published in:

Clinical Trials, 2025, v. 22, n. 4, p. 405, doi. 10.1177/17407745251338592

By:

Jin, Man

Publication type:

Article

Military influences on the evolution of clinical trials throughout history.

Published in:

Clinical Trials, 2025, v. 22, n. 4, p. 501, doi. 10.1177/17407745241309054

By:

Malshy, Kamil;
Steinmetz, Alexis;
Yuen, Kit;
Bandari, Jathin;
Rabinowitz, Ronald

Publication type:

Article

Cryo-EM reveals an extrahelical allosteric binding site at the M5 mAChR.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-62212-z

By:

Burger, Wessel A. C.;
Mobbs, Jesse I.;
Rana, Bhavika;
Wang, Jinan;
Joshi, Keya;
Gentry, Patrick R.;
Yeasmin, Mahmuda;
Venugopal, Hariprasad;
Bender, Aaron M.;
Lindsley, Craig W.;
Miao, Yinglong;
Christopoulos, Arthur;
Valant, Celine;
Thal, David M.

Publication type:

Article

New opportunities and current challenges using animal models for the discovery of novel countermeasures for acute radiation syndrome.

Published in:

Expert Opinion on Drug Discovery, 2025, v. 20, n. 8, p. 1045, doi. 10.1080/17460441.2025.2528966

By:

Singh, Vijay K.;
Seed, Thomas M.

Publication type:

Article

Synthesis, molecular modeling and harnessing the antimicrobial activity of new pyrazine-thiadiazole hybrids.

Published in:

BMC Chemistry, 2025, v. 19, n. 1, p. 1, doi. 10.1186/s13065-025-01587-y

By:

Abumelha, Hana M.;
Halawani, Nuha M.;
Alharbi, Abdulrahman S.;
Alsulami, Rabah N.;
Qurban, Jihan;
Alomari, Khadra B.;
Al-Bonayan, Ameena M.;
El-Metwaly, Nashwa

Publication type:

Article

Structure-based virtual screening, molecular docking, and MD simulation studies: An in-silico approach for identifying potential MBL inhibitors.

Published in:

PLoS ONE, 2025, v. 20, n. 7, p. 1, doi. 10.1371/journal.pone.0324836

By:

Noumi, Emira;
Snoussi, Mejdi;
Bouali, Nouha;
Alshammari, Mamdouh M.;
Altayb, Hisham N.;
Afzal, Muhammad;
De Feo, Vincenzo

Publication type:

Article

Obesity: A Persistent Puzzle-Unveiling Past Missteps and Future Promise in Drug Discovery.

Published in:

Karbala Journal of Pharmaceutical Sciences, 2024, v. 15, n. 25, p. 149, doi. 10.62472/kjps.v15.i25.149-174

By:

AlKhafaji, Sura L.;
Al-Owaidi, Mohammed Fanokh

Publication type:

Article

Hybrids of 4-aminoquinolines and adamantane as inhibitors of AChE.

Published in:

Journal of the Serbian Chemical Society, 2025, v. 90, n. 5, p. 545, doi. 10.2298/JSC250131014K

By:

KOMATOVIĆ, KATARINA;
MATOŠEVIĆ, ANA;
ZLATOVIĆ, MARIO;
SLADIĆ, DUŠAN;
BOSAK, ANITA;
OPSENICA, DEJAN M.

Publication type:

Article

Optimal Design of Drug–Drug Interaction Studies for the GLP‐1 Receptor Agonist Drug Class for Weight Management: Closing a Potential Data Gap.

Published in:

Journal of Clinical Pharmacology, 2025, v. 65, n. 8, p. 1056, doi. 10.1002/jcph.70020

By:

Weber, Elijah;
Trivedi, Ashit;
Barbour, April M.

Publication type:

Article