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- Title
Quantitation of HER2/neu expression in primary gastroesophageal adenocarcinomas using conventional light microscopy and quantitative image analysis.
- Authors
Jeung, Jennifer; Patel, Roshan; Vila, Lizette; Wakefield, Dara; Liu, Chen
- Abstract
Human epidermal growth factor receptor 2 (HER2/neu) is overexpressed in a proportion of gastroesophageal (GE) adenocarcinomas, and trastuzumab treatment results in significant improvement in overall survival in patients with HER2/neu-overexpressing GE tumors. Grading of HER2/neu expression in GE tumors and its clinical application is different from that of breast cancer. HER2/neu immunohistochemistry (IHC) image analysis (IA), widely used in breast cancer, has not been studied in GE tumors.
- Publication
Archives of pathology & laboratory medicine, 2012, Vol 136, Issue 6, p610
- ISSN
1543-2165
- Publication type
Journal Article
- DOI
10.5858/arpa.2011-0371-OA