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- Title
An Extranodal Nasal Natural Killer/T-Cell Lymphoma With Isochromosome 7q10 as the Sole Cytogenetic Aberration Was Initially Diagnosed Via Bone Marrow Biopsy.
- Authors
Huan-You Wang; Wilson, Kathleen S.; McKenna, Robert W.; Yin Xu; Karandikar, Nitin
- Abstract
We report a 58-year-old man who presented with fever, pancytopenia, hepatosplenomegaly, and ‘sinusitis’ of his right nostril. Flow cytometric analysis of his bone marrow aspirate revealed a population of cells that were CD56+ (bright), CD2+(dim), and CD7+ (slight brightly) but negative for CD3, CD4, CD5, CD8, CD11b, CD16, CD57, and T-cell receptors, consistent with aberrant natural killer cells. Bone marrow biopsy showed an atypical lymphoid infiltrate expressing CD56 as well as Epstein-Barr virus-encoded RNA and histiocytic hyperplasia with hemophagocytosis. Subsequent biopsy of his right nasal vestibule demonstrated an atypical lymphoid infiltrate, which was cytoplasmic CD3+, CD56+, and Epstein-Barr virus-encoded RNA positive, consistent with an extranodal nasal natural killer cell lymphoma. Conventional cytogenetic studies of the bone marrow revealed isochromosome 7q10 [i(7)(q10)] as the sole chromosomal aberration. To our knowledge, this is the first report demonstrating i(7)(q10) as a primary cytogenetic abnormality in an extranodal nasal natural killer cell lymphoma.
- Publication
Archives of Pathology & Laboratory Medicine, 2007, Vol 131, Issue 11, p1709
- ISSN
0003-9985
- Publication type
Academic Journal
- DOI
10.5858/2007-131-1709-aenntl