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- Title
Paneth cell carcinoma of the ampulla of Vater.
- Authors
Mora, Jorge I; Barroeta, Julieta E; Bernstein, David A; Lechago, Juan
- Abstract
We describe a Paneth cell carcinoma arising within the ampulla of Vater in a 64-year-old man. The phenotype of virtually all neoplastic cells was consistent with that of Paneth cells, based on routine morphology and their strong positive immunostaining for lysozyme. Additional widespread positive immunostaining for carcinoembryonic antigen and CA 19.9 supports a totipotential cell as the origin of such neoplastic cells. This case, therefore, represents a true Paneth cell carcinoma, as opposed to inclusion of occasional neoplastic Paneth cells into a poorly differentiated adenocarcinoma. This pattern of differentiation is rare, and predictions regarding its ultimate biological behavior and malignant potential must be guarded.
- Publication
Archives of pathology & laboratory medicine, 2004, Vol 128, Issue 8, p908
- ISSN
1543-2165
- Publication type
Journal Article
- DOI
10.5858/2004-128-908-PCCOTA