We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Follicular lymphoma with a burkitt translocation--predictor of an aggressive clinical course: a case report and review of the literature.
- Authors
Voorhees, Peter M; Carder, Kathryn A; Smith, Scott V; Ayscue, Lanier H; Rao, Kathleen W; Dunphy, Cherie H
- Abstract
Follicular lymphoma is an indolent lymphoma characterized by the (14;18) translocation, which leads to aberrant expression of Bcl-2. Translocations involving 8q24 are most commonly associated with Burkitt lymphoma and result in c-Myc overexpression. We report a case of follicular lymphoma of predominant small cleaved-cell type (grade 1) associated with both a t(14;18)(q32;q21) and a t(8;22)(q24;q11). The 8q24 translocation predicted an aggressive clinical course, as the lymphoma transformed into acute lymphoblastic leukemia within a year of initial diagnosis. Routine cytogenetic analysis is recommended at initial diagnosis of follicular lymphoma to better identify abnormalities that may predict prognosis and influence therapy.
- Publication
Archives of pathology & laboratory medicine, 2004, Vol 128, Issue 2, p210
- ISSN
1543-2165
- Publication type
Journal Article
- DOI
10.5858/2004-128-210-FLWABT