We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Histiocytic sarcoma associated with idiopathic myelofibrosis.
- Authors
Fukunaga, Masaharu; Kato, Hiroyuki
- Abstract
We describe the case of a 39-year-old man with idiopathic myelofibrosis, who developed histiocytic sarcoma (true histiocytic lymphoma) 6 months after diagnosis. The patient developed generalized lymphadenopathy. A lymph node biopsy showed pronounced distension of the sinuses in the medulla and periphery, caused by the accumulation of large tumor cells. The tumor cells had abundant clear or eosinophilic cytoplasm. The nuclei were of various sizes and shapes, with condensed chromatin and prominent nucleoli. Some tumor cells displayed erythrophagocytosis. Immunohistochemically, the tumor cells were positive for CD68, alpha(1)-antitrypsin, CD45, CD45RO, and S100 protein, and were negative for B- and T-cell markers, CD30, CD1a, lysozyme, myeloperoxidase, factor VIII-related antigen, CAM 5.2, and HMB-45. Despite multiagent chemotherapy, the patient died of disease 25 months after diagnosis. Although histiocytic sarcomas are very rare, their recognition may be important for clinical and prognostic reasons.
- Publication
Archives of pathology & laboratory medicine, 2004, Vol 128, Issue 10, p1167
- ISSN
1543-2165
- Publication type
Journal Article
- DOI
10.5858/2004-128-1167-HSAWIM