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- Title
Routine syndecan-1 immunohistochemistry aids in the diagnosis of chronic endometritis.
- Authors
Bayer-Garner, Ilene B; Nickell, Jennifer A; Korourian, Soheila
- Abstract
Chronic endometritis is reportedly observed in 3% to 10% of women undergoing endometrial biopsy for abnormal uterine bleeding. The diagnosis of chronic endometritis rests on the identification of the plasma cells. Their identification may be obscured by a mononuclear cell infiltrate, plasmacytoid stromal cells, abundant stromal mitoses, a pronounced predecidual reaction in late secretory endometrium, menstrual features, or secondary changes due to exogenous progesterone treatment prior to the biopsy. Syndecan-1 is a proteoglycan that is found on the cell surface of plasma cells and keratinocytes. Immunohistochemistry stains for this antibody may facilitate diagnosis of chronic endometritis.
- Publication
Archives of pathology & laboratory medicine, 2004, Vol 128, Issue 9, p1000
- ISSN
1543-2165
- Publication type
Journal Article
- DOI
10.5858/2004-128-1000-RSIAIT