We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
An Extracellular Matrix Molecule, Secreted by the Epithelial-Mesenchymal Transition is Associated With Lymph Node Metastasis of Thyroid Papillary Carcinoma.
- Authors
Takeyama, Hiroshi; Manome, Yoshinobu; Fujioka, Kouki; Tabei, Isao; Nogi, Hiroko; Toriumi, Yasuo; Kato, Kumiko; Kamio, Makiko; Imawari, Yoshimi; Kinoshita, Satoki; Akiba, Naoshi; Uchida, Ken; Morikawa, Toshiaki
- Abstract
Papillary thyroid carcinoma often has lymph node metastasis, compared with follicular thyroid carcinoma. The study showed that epithelial-mesenchymal transition occurs in carcinoma cells during the first stage of metastasis, where some extracellular matrix molecules are secreted in large quantities. Sialic acid carried by fibronectin as the antigen of the monoclonal antibody (MoAb) JT-95, was detected in 90% of papillary thyroid carcinoma cases, and in a few follicular thyroid carcinomas, in the extracellular matrix of thyroid carcinoma cells.
- Publication
International journal of endocrinology and metabolism, 2014, Vol 12, Issue 1, pe10748
- ISSN
1726-913X
- Publication type
Journal Article
- DOI
10.5812/ijem.10748