Title

Unraveling the Mechanisms of MicroRNA in Suppressing Hepatitis B Virus Progression: A Comprehensive Review for Designing Treatment Strategies.

Authors

Huanhuan Song; Qinghuai Zhang; Gang Fang; Xiaofan Luo; Di Wu; Hongyi Li; Kan Zhou; Xinyi Zhao; Fengmei Xu; Yun Zhang; An Huang

Abstract

Liver cancer and cirrhosis caused by the Hepatitis B virus (HBV) remain significant global health challenges due to the virus's high prevalence and contagious nature. Hepatitis B virus can be transmitted through various means, leading to mild or severe liver disease. Although an effective prophylactic vaccine is available, it offers limited benefits for those already chronically infected. Current treatments often fail to consistently eliminate the virus and can cause severe adverse effects. In response to these challenges, researchers have begun exploring microRNAs (miRNAs) as novel therapeutic targets. Studying miRNA-virus interactions presents a promising opportunity to identify potential therapeutic targets. By manipulating host miRNAs, researchers aim to enhance antiviral defenses, restore cellular balance, and prevent viral replication. The text concludes by highlighting the potential for personalized medicine in Hepatitis B treatment, guided by individual miRNA profiles. Numerous studies have been conducted to understand how different miRNAs inhibit HBV replication, paving the way for the development of innovative and effective therapeutic strategies.

Subjects

HEPATITIS B prevention; LIVER tumors; IMMUNIZATION; PHENOMENOLOGICAL biology; CIRRHOSIS of the liver; DRUG side effects; HEPATITIS viruses; RNA; ANTIVIRAL agents; GENES; HEPATITIS B; MICROBIOLOGY; INDIVIDUALIZED medicine; VACCINES; DISEASE progression; DISEASE complications

Publication

Hepatitis Monthly, 2024, Vol 24, Issue 1, p1

ISSN

1735-143X

Publication type

Academic Journal

DOI

10.5812/hepatmon-144239