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- Title
Digital pathology in personalized cancer therapy.
- Authors
Słodkowska, Janina; Rojo, Marcial Garcia
- Abstract
The development of small molecule inhibitors of growth factor receptors, and the discovery of somatic mutations of the tyrosine kinase domain, have resulted in new paradigms for cancer therapy. Digital microscopy is an important tool for surgical pathologists. The achievements in the digital pathology field have modified the workflow of pathomorphology labs, enhanced the pathologist's role in diagnostics, and increased their contribution to personalized targeted medicine. Digital image analysis is now available in a variety of platforms to improve quantification performance of diagnostic pathology. We here describe the state of digital microscopy as it applies to the field of quantitative immunohistochemistry of biomarkers related to the clinical personalized targeted therapy of breast cancer, non-small lung cancer and colorectal cancer: HER-2, EGFR, KRAS and BRAF genes. The information is derived from the experience of the authors and a review of the literature.
- Publication
Folia histochemica et cytobiologica, 2011, Vol 49, Issue 4, p570
- ISSN
1897-5631
- Publication type
Journal Article
- DOI
10.5603/fhc.2011.0080