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- Title
Random effects models in clinical research.
- Authors
Cleophas, T J; Zwinderman, A H
- Abstract
In clinical trials a fixed effects research model assumes that the patients selected for a specific treatment have the same true quantitative effect and that the differences observed are residual error. If, however, we have reasons to believe that certain patients respond differently from others, then the spread in the data is caused not only by the residual error but also by between-patient differences. The latter situation requires a random effects model.
- Publication
International journal of clinical pharmacology and therapeutics, 2008, Vol 46, Issue 8, p421
- ISSN
0946-1965
- Publication type
Journal Article
- DOI
10.5414/cpp46421