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- Title
Iron inhibits respiratory burst of peritoneal phagocytes in vitro.
- Authors
Gotfryd, Kamil; Jurek, Aleksandra; Kubit, Piotr; Klein, Andrzej; Turyna, Bohdan
- Abstract
Objective. This study examines the effects of iron ions Fe(3+) on the respiratory burst of phagocytes isolated from peritoneal effluents of continuous ambulatory peritoneal dialysis (CAPD) patients, as an in vitro model of iron overload in end-stage renal disease (ESRD). Material and Methods. Respiratory burst of peritoneal phagocytes was measured by chemiluminescence method. Results. At the highest used concentration of iron ions Fe(3+) (100 μM), free radicals production by peritoneal phagocytes was reduced by 90% compared to control. Conclusions. Iron overload may increase the risk of infectious complications in ESRD patients.
- Publication
ISRN urology, 2011, Vol 2011, p605436
- ISSN
2090-5815
- Publication type
Journal Article
- DOI
10.5402/2011/605436