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- Title
Ion channels in glioblastoma.
- Authors
Molenaar, Remco J
- Abstract
Glioblastoma is the most common primary brain tumor with the most dismal prognosis. It is characterized by extensive invasion, migration, and angiogenesis. Median survival is only 15 months due to this behavior, rendering focal surgical resection ineffective and adequate radiotherapy impossible. At this moment, several ion channels have been implicated in glioblastoma proliferation, migration, and invasion. This paper summarizes studies on potassium, sodium, chloride, and calcium channels of glioblastoma. It provides an up-to-date overview of the literature that could ultimately lead to new therapeutic targets.
- Publication
ISRN neurology, 2011, Vol 2011, p590249
- ISSN
2090-5513
- Publication type
Journal Article
- DOI
10.5402/2011/590249