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- Title
A 12-gene genomic instability signature predicts clinical outcomes in multiple cancer types.
- Authors
Mettu, Rama K R; Wan, Ying-Wooi; Habermann, Jens K; Ried, Thomas; Guo, Nancy Lan
- Abstract
Genomic instability, as reflected in specific chromosomal aneuploidies and variation in the nuclear DNA content, is a defining feature of human carcinomas. It is solidly established that the degree of genomic instability influences clinical outcome. We have recently identified a 12-gene expression signature that discerned genomically stable from unstable breast carcinomas. This gene expression signature was also useful to predict, with high accuracy, the clinical course in independent multiple published breast cancer cohorts. From a biological point of view, this result confirmed the central role of genomic instability for a tumor's ability to adapt to external challenges and selective pressure, and hence for continued survival fitness. This prompted us to investigate whether this genomic instability signature could also predict clinical outcome in other cancer types of epithelial origin, including colorectal tumors, non-small cell lung carcinomas, and ovarian cancer.
- Publication
The International journal of biological markers, 2010, Vol 25, Issue 4, p219
- ISSN
1724-6008
- Publication type
Journal Article
- DOI
10.5301/jbm.2010.6079