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- Title
Prevalence of High-risk Oropharyngeal Human Papillomavirus in Healthy Individuals.
- Authors
Mengi, Erdem; Kara, Cüneyt Orhan; Karakaya, Yeliz Arman; Bir, Ferda
- Abstract
Objective: This study aimed to evaluate the presence of oncogenic high-risk Human Papillomavirus (HR-HPV) in tonsil tissues with an in situ hybridization (ISH) technique and identify the prevalence of oropharyngeal HR-HPV in healthy individuals. Methods: The study was planned as a retrospective cross-sectional study. Cases of adult patients who had undergone a tonsillectomy procedure in our hospital in the years 2014-2018 were retrospectively reviewed. Patients who had tonsillectomy due to malignancy were excluded from the study. Two-hundred-and-twenty patients who were randomly selected based on age and gender were included in the study. Tonsil tissues of the included cases were reexamined by the pathology department and the presence of HPV in tonsil tissues was investigated with the ISH technique using a HR-HPV probe. Results: The prevalence of oropharyngeal HR-HPV was 6.8% (n=15) among the 220 patients included in the study, (154 [70%] were male; 66 [30%] were female with an age range from 17 to 66 years). Of the patients identified with HR-HPV, 13 (86.6%) were male and 2 (13.4%) were female and their mean age was 30.83±8.37 years. Prevalence rates were found 8.4% among male patients and 3% among female patients; while these rates were found 9.35% in patients aged less than 40 years and 2.46% in patients aged over 40 years. Conclusion: In our study, the prevalence of oncogenic HR-HPV in our region was found as 6.8%. Further, prevalence rates were found higher in young people and in males. This study, to the best of our knowledge, is the first study conducted in Turkey to determine the prevalence of oropharyngeal HR-HPV, but multicenter epidemiologic studies with larger series are needed on this subject.
- Publication
Turkish Archives of Otolaryngology / Türk Otolarengoloji Arsivi, 2019, Vol 57, pS10
- ISSN
0304-4793
- Publication type
Academic Journal
- DOI
10.5152/tao.2019.20012