Title

An overview and considerations in prescribing H<sub>1</sub>-antihistamine.

Authors

Yong Sung Choi; Yong Mean Park; Yeong Ho Rha; Sun Hee Choi

Abstract

H1-antihistamines have been prescribed widely for the treatment of allergic diseases, such as rhinitis, atopic dermatitis, and urticaria besides common colds since the 1940s. H1-antihistamines are classified by chemical structures (akylamine, piperazine, piperidine, ethanolamine, ethylendiamine, and phenothiazine) or functionally by permeability through blood brain barrier (first or second generation). The first generation antihistamines have been prescribed up to now with several adverse effects such as central nervous system dysfunction, anticholinergic and antiserotonic action and cardiotoxicity with overdose. Hence second generation antihistamines are recommended for the treatment of allergic rhinitis and urticaria. Physicians should consider concomitant diseases or medications when prescribing first generation antihistamines.

Subjects

ANTIHISTAMINES; MEDICAL protocols; MEDICAL prescriptions; THERAPEUTICS

Publication

Journal of the Korean Medical Association / Taehan Uisa Hyophoe Chi, 2013, Vol 56, Issue 3, p231

ISSN

1975-8456

Publication type

Academic Journal

DOI

10.5124/jkma.2013.56.3.231