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- Title
Effect of a Diet with Unrestricted Sodium on Ascites in Patients with Hepatic Cirrhosis.
- Authors
Xi-bing Gu; Xiao-juan Yang; Hong-ying Zhu; Bo-yu Xu
- Abstract
Background/Aims: There has been debate on whether a sodium-restricted diet (SRD) should be used in cirrhotic patients with ascites in China in recent years. The purpose of this study was to compare the effect of sodium-restricted and unrestricted diets on plasma renin activity (PRA), renal blood flow (RBF) and ascites in patients with liver cirrhosis. Methods: Two hundred cirrhotic patients with ascites were randomly divided into two groups (98 cases in the sodium-unrestricted diet [SUD] group and 102 cases in the SRD group); 95 patients (96.94%) in the SUD group and 97 patients (95.1%) in the SRD group had post-hepatitis B cir-rhosis. Results: Blood sodium and RBF were higher in SUD group than in SRD group (p<0.001), while PRA were signifi-cantly lower in SUD group than the SRD group 10 days after treatment (p<0.001). Renal impairment caused by low blood sodium was higher in SRD group than in SUD group (p<0.01). Ascites disappeared in higher proportion of patients in SUD group than in SRD group (p<0.001). Conclusions: SUD can increase the level of blood sodium and RBF, and be benefi-cial to diuresis and ascite reduction and disappearance.
- Publication
Gut & Liver, 2012, Vol 6, Issue 3, p355
- ISSN
1976-2283
- Publication type
Academic Journal
- DOI
10.5009/gnl.2012.6.3.355