Title

Evidence-based reproductive toxicity of propylthiouracil-induced hypothyroidism in sexually experienced male rats.

Authors

KEMKA NGUIMATIO, François Xavier; WANKEU NYA, Modeste; DEEH DEFO, Patrick Brice; NGADJUI, Esther; KAMANYI, Albert; KAMTCHOUING, Pierre; WATCHO, Pierre

Abstract

Hypothyroidism is associated with changes affecting the endocrine, sexual, or reproductive functions via a variety of mechanisms. To investigate some of the mechanisms involved in the reproductive abnormalities due to the hypothyroidism, the pathology was induced in male rats with propylthiouracil (PTU, 10 mg.kg-1 ; per os). Two experiments were conducted. In experiment 1, the effects of hypothyroidism were evaluated on sexual activity after 28 days of PTU treatment. In experiment 2, rats were treated for 56 days and testicular functions, histological analysis as well as fertility were evaluated. Results showed that 28 and 56 days of PTU treatment induced the hypothyroid status. PTU significantly alters sexual behavior, lowered genital sex organ weights, sperm count, viability and motility, sex hormones, and, increased prolactin, cholesterol and testicular oxidative stress. Alterations in sperm morphology, testis histology and fertility potential were also noticed. These results provide further evidence that hypothyroidism seriously impairs sexual behavior, testis functions and fertility of male rat.

Subjects

HYPOTHYROIDISM; OXIDATIVE stress; HUMAN sexuality

Publication

Cameroon Journal of Experimental Biology, 2019, Vol 13, Issue 1, p10

ISSN

1816-0573

Publication type

Academic Journal

DOI

10.4314/cajeb.v13i1.2