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- Title
TLR9 polymorphisms are associated with altered IFN-gamma levels in children with cerebral malaria.
- Authors
Sam-Agudu, Nadia A; Greene, Jennifer A; Opoka, Robert O; Kazura, James W; Boivin, Michael J; Zimmerman, Peter A; Riedesel, Melissa A; Bergemann, Tracy L; Schimmenti, Lisa A; John, Chandy C
- Abstract
Toll-like receptor (TLR) polymorphisms have been associated with disease severity in malaria infection, but mechanisms for this association have not been characterized. The TLR2, 4, and 9 single nucleotide polymorphism (SNP) frequencies and serum interferon-gamma (IFN-gamma) and tumor necrosis factor-alpha (TNF-alpha) levels were assessed in Ugandan children with cerebral malaria (CM, N = 65) and uncomplicated malaria (UM, N = 52). The TLR9 C allele at -1237 and G allele at 1174 were strongly linked, and among children with CM, those with the C allele at -1237 or the G allele at 1174 had higher levels of IFN-gamma than those without these alleles (P = 0.03 and 0.008, respectively). The TLR9 SNPs were not associated with altered IFN-gamma levels in children with UM or altered TNF-alpha levels in either group. We present the first human data that TLR SNPs are associated with altered cytokine production in parasitic infection.
- Publication
The American journal of tropical medicine and hygiene, 2010, Vol 82, Issue 4, p548
- ISSN
1476-1645
- Publication type
Journal Article
- DOI
10.4269/ajtmh.2010.09-0467