We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Transcription regulation by distal enhancers: who's in the loop?
- Authors
Stadhouders, Ralph; van den Heuvel, Anita; Kolovos, Petros; Jorna, Ruud; Leslie, Kris; Grosveld, Frank; Soler, Eric
- Abstract
Genome-wide chromatin profiling efforts have shown that enhancers are often located at large distances from gene promoters within the noncoding genome. Whereas enhancers can stimulate transcription initiation by communicating with promoters via chromatin looping mechanisms, we propose that enhancers may also stimulate transcription elongation by physical interactions with intronic elements. We review here recent findings derived from the study of the hematopoietic system.
- Publication
Transcription, 2012, Vol 3, Issue 4, p181
- ISSN
2154-1272
- Publication type
Journal Article
- DOI
10.4161/trns.20720