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- Title
The HIV-1 Rev response element: an RNA scaffold that directs the cooperative assembly of a homo-oligomeric ribonucleoprotein complex.
- Authors
Fernandes, Jason; Jayaraman, Bhargavi; Frankel, Alan
- Abstract
The HIV-1 Rev response element (RRE) is a ~350 nucleotide, highly structured, cis-acting RNA element essential for viral replication. It is located in the env coding region of the viral genome and is extremely well conserved across different HIV-1 isolates. It is present on all partially spliced and unspliced viral mRNA transcripts, and serves as an RNA framework onto which multiple molecules of the viral protein Rev assemble. The Rev-RRE oligomeric complex mediates the export of these messages from the nucleus to the cytoplasm, where they are translated to produce essential viral proteins and/or packaged as genomes for new virions.
- Publication
RNA biology, 2012, Vol 9, Issue 1, p6
- ISSN
1555-8584
- Publication type
Journal Article
- DOI
10.4161/rna.9.1.18178