We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
T-body formation precedes virus-like particle maturation in S. cerevisiae.
- Authors
Malagon, Francisco; Jensen, Torben Heick
- Abstract
T-bodies are localized S. cerevisiae RNPs containing Ty1 retroviral components and speculated to play a role in the assembly of virus-like particles (VLPs). Mapping requirements for T-body formation, we demonstrate that ectopic expression of immature TyA1/Gag (Gag-p49), a structural component of the Ty1 capsid, is sufficient for T-body formation both under normal conditions as well as in a strain background devoid of endogenous Gag. Moreover, T-bodies are readily formed when Ty1 transposition is blocked. Thus, T-bodies represent an early stage in the Ty1 life cycle, preceding VLP maturation.
- Publication
RNA biology, 2011, Vol 8, Issue 2, p184
- ISSN
1555-8584
- Publication type
Journal Article
- DOI
10.4161/rna.8.2.14822