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- Title
The A-nucleotide preference of HIV-1 in the context of its structured RNA genome.
- Authors
van Hemert, Formijn J; van der Kuyl, Antoinette C; Berkhout, Ben
- Abstract
A bipartition of HIV-1 RNA genome sequences into single- and double-stranded nucleotides is possible based on the secondary structure model of a complete 9 kb genome. Subsequent analysis revealed that the well-known lentiviral property of A-accumulation is profoundly present in single-stranded domains, yet absent in double-stranded domains. Mutational rate analysis by means of an unrestricted model of nucleotide substitution suggests the presence of an evolutionary equilibrium to preserve this biased nucleotide distribution.
- Publication
RNA biology, 2013, Vol 10, Issue 2, p211
- ISSN
1555-8584
- Publication type
Journal Article
- DOI
10.4161/rna.22896