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- Title
Comparative analysis of Japanese and foreign L-type BSE prions.
- Authors
Masujin, Kentaro; Miwa, Ritsuko; Okada, Hiroyuki; Mohri, Shirou; Yokoyama, Takashi
- Abstract
L-type bovine spongiform encephalopathy (BSE) is an atypical form of BSE. To characterize the Japanese L-type BSE prion, we conducted a comparative study of the Japanese and foreign L-type BSE isolates. The L-type BSE isolates of Japan, Germany, France and Canada were intracerebrally inoculated into bovinized prion protein-overexpressing transgenic mice (TgBoPrP). All the examined L-type BSE isolates were transmitted to TgBoPrP mice, and no clear differences were observed in their biological and biochemical properties. Here, we present evidence that the Japanese and Canadian L-type BSE prions are identical to those from the European cases.
- Publication
Prion, 2012, Vol 6, Issue 1, p89
- ISSN
1933-690X
- Publication type
Journal Article
- DOI
10.4161/pri.6.1.18429