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- Title
Immunotherapy with artificial adjuvant vector cells: Harnessing both arms of the immune response.
- Authors
Fujii, Shin-Ichiro; Shimizu, Kanako
- Abstract
Both innate and adaptive immunity underpin cancer immunosurveillance. To stimulate both these arms of the immune system, we used allogeneic cells loaded with natural killer T (NKT) cell ligands and expressing tumor-associated antigens, resulting in NKT cell activation, dendritic-cell maturation and ultimately in the elicitation of adaptive T-cell responses. This approach holds great promise for the development of novel anticancer immunotherapies.
- Publication
Oncoimmunology, 2013, Vol 2, Issue 4, pe23432
- ISSN
2162-4011
- Publication type
Journal Article
- DOI
10.4161/onci.23432