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- Title
Targeting the tumor mutanome for personalized vaccination therapy.
- Authors
Kreiter, Sebastian; Castle, John C; Türeci, Ozlem; Sahin, Ugur
- Abstract
Next generation sequencing enables identification of immunogenic tumor mutations targetable by individualized vaccines. In the B16F10 melanoma system as pre-clinical proof-of-concept model, we found a total of 563 non-synonymous expressed somatic mutations. Of the mutations we tested, one third were immunogenic. Immunization conferred in vivo tumor control, qualifying mutated epitopes as source for effective vaccines.
- Publication
Oncoimmunology, 2012, Vol 1, Issue 5, p768
- ISSN
2162-4011
- Publication type
Journal Article
- DOI
10.4161/onci.19727