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Title
Engineering hematopoietic stem cells to create melanoma specific CTL.
Authors
Vatakis, Dimitrios
Abstract
Using a humanized mouse model, we developed melanoma specific CD8 T cells from genetically modified human hematopoietic stem cells (hHSC). The transgenic T cells were functional both in vivo and ex vivo, effectively limiting and clearing tumor growth. Finally, the transduced hHSC stably populated the bone marrow.