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- Title
Modulation of chromatin access during adipocyte differentiation.
- Authors
Mandrup, Susanne; Hager, Gordon L
- Abstract
Cellular development requires reprogramming of the genome to modulate the gene program of the undifferentiated cell and allow expression of the gene program unique to differentiated cells. A number of key transcription factors involved in this reprogramming of preadipocytes to adipocytes have been identified; however, it is not until recently that we have begun to understand how these factors act at a genome-wide scale. In a recent publication we have mapped the genome-wide changes in chromatin structure during differentiation of 3T3-L1 preadipocytes and shown that a major reorganization of the chromatin landscape occurs within few hours following the addition of the adipogenic cocktail. In addition, we have mapped the genome-wide profiles of several of the early adipogenic transcription factors and shown that they act in a highly cooperative manner to drive this dramatic remodeling process.
- Publication
Nucleus (Austin, Tex.), 2012, Vol 3, Issue 1, p12
- ISSN
1949-1042
- Publication type
Journal Article
- DOI
10.4161/nucl.18928