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- Title
The meiosis-specific modification of mammalian telomeres.
- Authors
Shibuya, Hiroki; Watanabe, Yoshinori
- Abstract
During meiosis, rapid chromosome movements within the nucleus enable homologous chromosomes to acquire physical juxtaposition. In most organisms, chromosome ends, telomeres, tethered to the transmembrane LINC-complex mediate this movement by transmitting cytoskeletal forces to the chromosomes. While the majority of molecular studies have been performed using lower eukaryotes as model systems, recent studies have identified mammalian meiotic telomere regulators, including the LINC-complex SUN1/KASH5 and the meiosis-specific telomere binding protein TERB1. This review highlights the molecular regulations of mammalian meiotic telomeres in comparison with other model systems and discusses some future perspectives.
- Publication
Cell cycle (Georgetown, Tex.), 2014, Vol 13, Issue 13, p2024
- ISSN
1551-4005
- Publication type
Journal Article
- DOI
10.4161/cc.29350