We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
MicroRNA-143 inhibits tumor growth and angiogenesis and sensitizes chemosensitivity to oxaliplatin in colorectal cancers.
- Authors
Qian, Xu; Yu, Jing; Yin, Yu; He, Jun; Wang, Lin; Li, Qi; Zhang, Lou-Qian; Li, Chong-Yong; Shi, Zhu-Mei; Xu, Qing; Li, Wei; Lai, Li-Hui; Liu, Ling-Zhi; Jiang, Bing-Hua
- Abstract
Colorectal cancer (CRC) is one of the leading cancer-related causes of death in the world. Recently, downregulation of microRNA-143 (miR-143) has been observed in CRC tissues. Here in this study, we found that miR-143 expression was downregulated both in CRC patients' blood samples and tumor specimens. MiR-143 expression levels were strongly correlated with clinical stages and lymph node metastasis. Furthermore, insulin-like growth factor-I receptor (IGF-IR), a known oncogene, was a novel direct target of miR-143, whose expression levels were inversely correlated with miR-143 expression in human CRC specimens. Overexpression of miR-143 inhibited cell proliferation, migration, tumor growth and angiogenesis and increased chemosensitivity to oxaliplatin treatment in an IGF-IR-dependent manner. Taken together, these results revealed that miR-143 levels in human blood and tumor tissues are associated with CRC cancer occurrence, metastasis and drug resistance, and miR-143 levels may be used as a new diagnostic marker and therapeutic target for CRC in the future.
- Publication
Cell cycle (Georgetown, Tex.), 2013, Vol 12, Issue 9, p1385
- ISSN
1551-4005
- Publication type
Journal Article
- DOI
10.4161/cc.24477