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- Title
Co-expression of matrix metalloproteinase-7 (MMP-7) and phosphorylated insulin growth factor receptor I (pIGF-1R) correlates with poor prognosis in patients with wild-type KRAS treated with cetuximab or panitumumab: a GEMCAD study.
- Authors
Hörndler, Carlos; Gallego, Rosa; García-Albeniz, Xabier; Alonso-Espinaco, Virginia; Alonso, Vicente; Escudero, Pilar; Jimeno, Mireya; Ortego, Javier; Codony-Servat, Jordi; Fernández-Martos, Carlos; Calatrava, Ana; Marín-Aguilera, Mercedes; Muñoz, Jenifer; Castellví-Bel, Sergi; Castells, Antoni; Rubini, Michele; Gascón, Pere; Maurel, Joan
- Abstract
By transactivacion, phosphorylated insulin growth factor receptor I (IGF-1R) can activate epidermal growth factor receptor (EGFR). MMP-7, produced by colorectal cancer cells, also can activate IGF-1R by degrading IGFBP-3 and releasing IGF-I.
- Publication
Cancer biology & therapy, 2011, Vol 11, Issue 2, p177
- ISSN
1555-8576
- Publication type
Journal Article
- DOI
10.4161/cbt.11.2.13839