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Title
Presenilins mediate efficient proteolysis via the autophagosome-lysosome system.
Authors
Neely, Kara M; Green, Kim N
Abstract
Degradation through the lysosome involves careful orchestration of numerous molecular players in concert. Many of these key molecular players remain to be identified. We find that wild-type presenilins play a key role in degradation through the autophagy-lysosome system by modulating either fusion of autophagosomes to lysosomes or lysosome function.