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- Title
Context effect: microRNA-10b in cancer cell proliferation, spread and death.
- Authors
Gabriely, Galina; Teplyuk, Nadiya M; Krichevsky, Anna M
- Abstract
Single microRNA (miRNA) can regulate expression of several or multiple principal targets in a specific microenvironment. In different cellular contexts, the same miRNA may exhibit diverse functions, depending on the repertoire and stoichiometry of its direct mRNA targets. For instance, in breast cancer, microRNA-10b (miR-10b) promotes invasion and metastasis of tumor cells through post-transcriptional regulation of HOXD10. In contrast, in glioblastoma (GBM), the most common and malignant primary brain tumor, miR-10b promotes proliferation and prevents death of cancer cells by targeting cell cycle inhibitors and pro-apoptotic genes. Here, we discuss a unique role of miR-10b in cancer cell survival, in diverse tumor microenvironments.
- Publication
Autophagy, 2011, Vol 7, Issue 11, p1384
- ISSN
1554-8635
- Publication type
Journal Article
- DOI
10.4161/auto.7.11.17371